Small molecule recognition of disease-relevant RNA structures
SM Meyer, CC Williams, Y Akahori, T Tanaka… - Chemical Society …, 2020 - pubs.rsc.org
Targeting RNAs with small molecules represents a new frontier in drug discovery and
development. The rich structural diversity of folded RNAs offers a nearly unlimited reservoir …
development. The rich structural diversity of folded RNAs offers a nearly unlimited reservoir …
Small molecule approaches to targeting RNA
S Kovachka, M Panosetti, B Grimaldi… - Nature Reviews …, 2024 - nature.com
The development of innovative methodologies to identify RNA binders has attracted
enormous attention in chemical biology and drug discovery. Although antibiotics targeting …
enormous attention in chemical biology and drug discovery. Although antibiotics targeting …
Molecular engineering of guanine-rich sequences: Z-DNA, DNA triplexes, and G-quadruplexes
O Doluca, JM Withers, VV Filichev - Chemical reviews, 2013 - ACS Publications
Guanine's array of hydrogen bond donors and acceptors lead it to take part in structures as
diverse as B-DNA, Z-DNA, hairpins, cruciforms, triplexes, and G-quadruplexes; these …
diverse as B-DNA, Z-DNA, hairpins, cruciforms, triplexes, and G-quadruplexes; these …
Enhancer remodeling promotes tumor-initiating activity in NRF2-activated non-small cell lung cancers
K Okazaki, H Anzawa, Z Liu, N Ota, H Kitamura… - Nature …, 2020 - nature.com
Transcriptional dysregulation, which can be caused by genetic and epigenetic alterations, is
a fundamental feature of many cancers. A key cytoprotective transcriptional activator, NRF2 …
a fundamental feature of many cancers. A key cytoprotective transcriptional activator, NRF2 …
A review of currently identified small molecule modulators of microRNA function
EN Van Meter, JA Onyango, KA Teske - European journal of medicinal …, 2020 - Elsevier
Abstract microRNAs are small, noncoding RNA that negatively regulate gene expression.
Since their discovery in 1993, approximately 2500 human mature microRNAs have been …
Since their discovery in 1993, approximately 2500 human mature microRNAs have been …
Targeting the production of oncogenic microRNAs with multimodal synthetic small molecules
MicroRNAs (miRNAs) are a recently discovered category of small RNA molecules that
regulate gene expression at the post-transcriptional level. Accumulating evidence indicates …
regulate gene expression at the post-transcriptional level. Accumulating evidence indicates …
Sequence-selective recognition of double-stranded RNA and enhanced cellular uptake of cationic nucleobase and backbone-modified peptide nucleic acids
Sequence-selective recognition of complex RNAs in live cells could find broad applications
in biology, biomedical research, and biotechnology. However, specific recognition of …
in biology, biomedical research, and biotechnology. However, specific recognition of …
Design and implementation of synthetic RNA binders for the inhibition of miR-21 biogenesis
C Maucort, DD Vo, S Aouad, C Charrat… - ACS medicinal …, 2021 - ACS Publications
Targeting RNAs using small molecules is an emerging field of medicinal chemistry and
holds promise for the discovery of efficient tools for chemical biology. MicroRNAs are …
holds promise for the discovery of efficient tools for chemical biology. MicroRNAs are …
Fluorogenic thiazole orange TOTFO probes stabilise parallel DNA triplexes at pH 7 and above
The instability of DNA triplexes particularly at neutral pH and above severely limits their
applications. Here, we demonstrate that the introduction of a thiazole orange (TO) …
applications. Here, we demonstrate that the introduction of a thiazole orange (TO) …
Building of neomycin–nucleobase–amino acid conjugates for the inhibition of oncogenic miRNAs biogenesis
MicroRNAs (miRNAs) are a recently discovered category of small RNA molecules that
regulate gene expression at the post-transcriptional level. Accumulating evidence indicates …
regulate gene expression at the post-transcriptional level. Accumulating evidence indicates …