The role of oxidative stress in organophosphate and nerve agent toxicity

JN Pearson, M Patel - Annals of the New York Academy of …, 2016 - Wiley Online Library
Organophosphate (OP) nerve agents exert their toxicity through inhibition of
acetylcholinesterase. The excessive stimulation of cholinergic receptors rapidly causes …

Acetylcholinesterase inhibitors (nerve agents) as weapons of mass destruction: History, mechanisms of action, and medical countermeasures

V Aroniadou-Anderjaska, JP Apland, TH Figueiredo… - …, 2020 - Elsevier
Nerve agents are organophosphorus acetylcholinesterase inhibitors. Acute exposure to
nerve agents can cause rapid death. In this review, we summarize the history of nerve agent …

Organophosphorus pesticides can influence the development of obesity and type 2 diabetes with concomitant metabolic changes

M Czajka, M Matysiak-Kucharek… - Environmental …, 2019 - Elsevier
Widespread use and the bioaccumulation of pesticides in the environment lead to the
contamination of air, water, soil and agricultural resources. A huge body of evidence points …

DNA-based sensor for the detection of an organophosphorus pesticide: Profenofos

G Selvolini, I Băjan, O Hosu, C Cristea, R Săndulescu… - Sensors, 2018 - mdpi.com
In this work, we propose an electrochemical DNA aptasensor for the detection of profenofos,
an organophosphorus pesticide, based on a competitive format and disposable graphite …

[HTML][HTML] Midazolam-a diazepam replacement for the management of nerve agent-induced seizures.

L Gorecki, J Pejchal, C Torruellas, J Korabecny… - …, 2024 - Elsevier
A benzodiazepine, diazepam, has been the leading antidote for seizures caused by nerve
agents, the most toxic chemical weapons of mass destruction, since the 1960s. However, its …

[HTML][HTML] Repeated low-dose organophosphate DFP exposure leads to the development of depression and cognitive impairment in a rat model of Gulf War Illness

KF Phillips, LS Deshpande - Neurotoxicology, 2016 - Elsevier
Abstract Approximately 175,000–250,000 of the returning veterans from the 1991 Persian
Gulf War exhibit chronic multi-symptom illnesses that includes neurologic co-morbidities …

Animal models of status epilepticus and temporal lobe epilepsy: a narrative review

N Nirwan, P Vyas, D Vohora - Reviews in the Neurosciences, 2018 - degruyter.com
Temporal lobe epilepsy (TLE) is the chronic and pharmacoresistant form of epilepsy
observed in humans. The current literature is insufficient in explicating the comprehensive …

Nanocrystalline cerium oxide for catalytic degradation of paraoxon methyl: Influence of CeO2 surface properties

J Ederer, P Janoš, M Šťastný, J Henych… - Journal of …, 2021 - Elsevier
Cerium oxide (CeO 2) prepared by annealing of carbonate precursor was tested for
degradation of paraoxon methyl (PO) and the relationships between its properties (specific …

[HTML][HTML] Inducible nitric oxide synthase inhibitor, 1400W, mitigates DFP-induced long-term neurotoxicity in the rat model

M Putra, S Sharma, M Gage, G Gasser… - Neurobiology of …, 2020 - Elsevier
Chemical nerve agents (CNA) are increasingly becoming a threat to both civilians and
military personnel. CNA-induced acute effects on the nervous system have been known for …

Targeting the glutamatergic system to counteract organophosphate poisoning: A novel therapeutic strategy

V Aroniadou-Anderjaska, TH Figueiredo… - Neurobiology of …, 2020 - Elsevier
One of the devastating effects of acute exposure to organophosphates, like nerve agents, is
the induction of severe and prolonged status epilepticus (SE), which can cause death, or …