Crosstalk between the renin–angiotensin, complement and kallikrein–kinin systems in inflammation
Z Bekassy, I Lopatko Fagerström, M Bader… - Nature Reviews …, 2022 - nature.com
During severe inflammatory and infectious diseases, various mediators modulate the
equilibrium of vascular tone, inflammation, coagulation and thrombosis. This Review …
equilibrium of vascular tone, inflammation, coagulation and thrombosis. This Review …
Clinical promise of next-generation complement therapeutics
The complement system plays a key role in pathogen immunosurveillance and tissue
homeostasis. However, subversion of its tight regulatory control can fuel a vicious cycle of …
homeostasis. However, subversion of its tight regulatory control can fuel a vicious cycle of …
Direct activation of the alternative complement pathway by SARS-CoV-2 spike proteins is blocked by factor D inhibition
J Yu, X Yuan, H Chen, S Chaturvedi… - Blood, The Journal …, 2020 - ashpublications.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a highly contagious
respiratory virus that can lead to venous/arterial thrombosis, stroke, renal failure, myocardial …
respiratory virus that can lead to venous/arterial thrombosis, stroke, renal failure, myocardial …
Novel mechanisms and functions of complement
Progress at the beginning of the 21st century transformed the perception of complement
from that of a blood-based antimicrobial system to that of a global regulator of immunity and …
from that of a blood-based antimicrobial system to that of a global regulator of immunity and …
Complement system part I–molecular mechanisms of activation and regulation
NS Merle, SE Church, V Fremeaux-Bacchi… - Frontiers in …, 2015 - frontiersin.org
Complement is a complex innate immune surveillance system, playing a key role in defense
against pathogens and in host homeostasis. The complement system is initiated by …
against pathogens and in host homeostasis. The complement system is initiated by …
Complement component C3–The “Swiss Army Knife” of innate immunity and host defense
As a preformed defense system, complement faces a delicate challenge in providing an
immediate, forceful response to pathogens even at first encounter, while sparing host cells in …
immediate, forceful response to pathogens even at first encounter, while sparing host cells in …
Complement proteins bind to nanoparticle protein corona and undergo dynamic exchange in vivo
F Chen, G Wang, JI Griffin, B Brenneman… - Nature …, 2017 - nature.com
When nanoparticles are intravenously injected into the body, complement proteins deposit
on the surface of nanoparticles in a process called opsonization. These proteins prime the …
on the surface of nanoparticles in a process called opsonization. These proteins prime the …
The renaissance of complement therapeutics
D Ricklin, DC Mastellos, ES Reis… - Nature Reviews …, 2018 - nature.com
The increasing number of clinical conditions that involve a pathological contribution from the
complement system—many of which affect the kidneys—has spurred a regained interest in …
complement system—many of which affect the kidneys—has spurred a regained interest in …
Complement, a target for therapy in inflammatory and degenerative diseases
The complement system is a key innate immune defence against infection and an important
driver of inflammation; however, these very properties can also cause harm. Inappropriate or …
driver of inflammation; however, these very properties can also cause harm. Inappropriate or …
Complement activation, regulation, and molecular basis for complement‐related diseases
The complement system is an essential element of the innate immune response that
becomes activated upon recognition of molecular patterns associated with microorganisms …
becomes activated upon recognition of molecular patterns associated with microorganisms …