[HTML][HTML] The design and application of DNA-editing enzymes as base editors
KL Rallapalli, AC Komor - Annual review of biochemistry, 2023 - annualreviews.org
DNA-editing enzymes perform chemical reactions on DNA nucleobases. These reactions
can change the genetic identity of the modified base or modulate gene expression. Interest …
can change the genetic identity of the modified base or modulate gene expression. Interest …
[HTML][HTML] The coevolution between APOBEC3 and retrotransposons in primates
G Modenini, P Abondio, A Boattini - Mobile DNA, 2022 - Springer
Retrotransposons are genetic elements with the ability to replicate in the genome using
reverse transcriptase: they have been associated with the development of different …
reverse transcriptase: they have been associated with the development of different …
[HTML][HTML] Structure-guided inhibition of the cancer DNA-mutating enzyme APOBEC3A
The normally antiviral enzyme APOBEC3A is an endogenous mutagen in human cancer. Its
single-stranded DNA C-to-U editing activity results in multiple mutagenic outcomes including …
single-stranded DNA C-to-U editing activity results in multiple mutagenic outcomes including …
Cryo-EM structure of the EBV ribonucleotide reductase BORF2 and mechanism of APOBEC3B inhibition
Viruses use a plethora of mechanisms to evade immune responses. A recent example is
neutralization of the nuclear DNA cytosine deaminase APOBEC3B by the Epstein-Barr virus …
neutralization of the nuclear DNA cytosine deaminase APOBEC3B by the Epstein-Barr virus …
Evidence linking APOBEC3B genesis and evolution of innate immune antagonism by gamma-herpesvirus ribonucleotide reductases
Viruses have evolved diverse mechanisms to antagonize host immunity such as direct
inhibition and relocalization of cellular APOBEC3B (A3B) by the ribonucleotide reductase …
inhibition and relocalization of cellular APOBEC3B (A3B) by the ribonucleotide reductase …
[HTML][HTML] Structural insights into RNA bridging between HIV-1 Vif and antiviral factor APOBEC3G
T Kouno, S Shibata, M Shigematsu, J Hyun… - Nature …, 2023 - nature.com
Great effort has been devoted to discovering the basis of A3G-Vif interaction, the key event
of HIV's counteraction mechanism to evade antiviral innate immune response. Here we …
of HIV's counteraction mechanism to evade antiviral innate immune response. Here we …
[HTML][HTML] Engineered CBEs based on Macaca fascicularis A3A with improved properties for precise genome editing
CY Ren, YS Liu, YS He, LP Zhang, JH Rao, Y Rao… - Cell Reports, 2024 - cell.com
Cytidine deaminase defines the properties of cytosine base editors (CBEs) for C-to-T
conversion. Replacing the cytidine deaminase rat APOBEC1 (rA1) in CBEs with a human …
conversion. Replacing the cytidine deaminase rat APOBEC1 (rA1) in CBEs with a human …
Oncogenic Merkel cell polyomavirus T antigen truncating mutations are mediated by APOBEC3 activity in Merkel cell carcinoma
AI Soikkeli, MK Kyläniemi, H Sihto, J Alinikula - Cancer research …, 2022 - AACR
Merkel cell carcinoma (MCC) is an aggressive skin cancer, which is frequently caused by
Merkel cell polyomavirus (MCPyV). Mutations of MCPyV tumor (T) antigens are major …
Merkel cell polyomavirus (MCPyV). Mutations of MCPyV tumor (T) antigens are major …
[HTML][HTML] Exploring APOBEC3A and APOBEC3B substrate specificity and their role in HPV positive head and neck cancer
APOBEC3 family members are cytidine deaminases catalyzing conversion of cytidine to
uracil. Many studies have established a link between APOBEC3 expression and cancer …
uracil. Many studies have established a link between APOBEC3 expression and cancer …
[HTML][HTML] Predicting clinical outcomes using cancer progression associated signatures
Somatic mutation signatures are an informative facet of cancer aetiology, however they are
rarely useful for predicting patient outcome. The aim of this study is to evaluate the utility of a …
rarely useful for predicting patient outcome. The aim of this study is to evaluate the utility of a …