Natural products have had an immense influence on science and have directly led to the
introduction of many drugs. Organic chemistry, and its unique ability to tailor natural products …

Macrocycles are typically cyclic variants of inhibitors derived from uncyclized canonical
molecules or from natural products. For medicinal chemistry, drug-like macrocycles have …

Covering: up to the end of 2014 Polyketides represent an important class of secondary
metabolites that interact with biological targets connected to a variety of disease-associated …

Bryostatins are a class of naturally occurring macrocyclic lactones with a unique fast
developing portfolio of clinical applications, including treatment of AIDS, Alzheimer's …

Microglia and CNS-infiltrating macrophages play significant roles in the pathogenesis of
neuroinflammatory and neurodegenerative diseases, such as Alzheimer's disease …

The synthesis and biological evaluation of chromane-containing bryostatin analogues WN-2–
WN-7 and the previously reported salicylate-based analogue WN-8 are described …

Protein kinase C (PKC) modulators are currently of great importance in preclinical and
clinical studies directed at cancer, immunotherapy, HIV eradication, and Alzheimer's …

Methyl-aplog-1 (1), a simplified analog of tumor-promoting aplysiatoxin, is a potential lead
for cancer therapy that exhibits marked and selective growth inhibitory effects against …

Bryostatin 1, a complex macrocyclic lactone isolated from Bugula neritina, has been the
subject of multiple clinical trials for cancer. Although it functions as an activator of protein …

Chikungunya virus (CHIKV) is a mosquito-borne alphavirus showing a recent resurgence
and rapid spread worldwide. While vaccines are under development, there are currently no …