Oncogenic KRAS (KRAS*) contributes to many cancer hallmarks. In colorectal cancer,
KRAS* suppresses antitumor immunity to promote tumor invasion and metastasis. Here, we …

Type 2 diabetes (T2D) is a common chronic disease whose etiology is known to have a
strong genetic component. Standard genetic approaches, although allowing for the …

Background Numerous studies indicate an association between neurodegenerative and
metabolic diseases. Although still a matter of debate, growing evidence from …

Quantitative PCR (qPCR), the most accurate and sensitive technique for quantifying mRNA
expression, and choice of appropriate reference genes for internal error controlling in qPCR …

Post-exercise recovery is essential to resolve metabolic perturbations and promote long-
term cellular remodeling in response to exercise. Here, we report that muscle-generated …

Multiple statistical approaches have been proposed to validate reference genes in qPCR
assays. However, conflicting results from these statistical methods pose a major hurdle in …

Branched-chain α-keto acids (BCKAs) are catabolites of branched-chain amino acids
(BCAAs). Intracellular BCKAs are cleared by branched-chain ketoacid dehydrogenase …

Autotaxin (ATX) is an adipokine that generates the bioactive lipid, lysophosphatidic acid
(LPA). ATX-LPA signaling has been implicated in diet-induced obesity and systemic insulin …

Transcription factor EB (TFEB) is a master regulator of lysosomal biogenesis and autophagy
with critical roles in several cancers. Lysosomal autophagy promotes cancer survival …

The objective was to examine the effectiveness of mate tea (MT, Ilex paraguariensis St.
Hilaire) and caffeine from mate tea (MC) on in vitro lipid accumulation and in vivo diet-driven …