Members of the protein superfamily of small guanosine triphosphatases, also known as
small GTPases, small G-proteins, or the Ras superfamily, are involved in nearly every aspect …

The correct wiring of neuronal circuits depends on outgrowth and guidance of neuronal
processes during development. In the past two decades, great progress has been made in …

TRIM9 and TRIM67 are neuronally enriched E3 ubiquitin ligases essential for appropriate
morphogenesis of cortical and hippocampal neurons and fidelitous responses to the axon …

A fundamental feature of both early nervous system development and axon regeneration is
the guidance of axonal projections to their targets in order to assemble neural circuits that …

The mechanisms linking guidance receptors to cytoskeletal dynamics in the growth cone
during axon extension remain mysterious. The Rho-family GTPases Rac and CDC-42 are …

Introduction: UNC-6/Netrin is a conserved bi-functional guidance cue which regulates dorsal-
ventral axon guidance in C. elegans. In the Polarity/Protrusion model of UNC-6/Netrin …

At present, the majority of investigations concerning nanotoxicology in the nematode C.
elegans address short-term effects. While this approach allows for the identification of …

UNC-6/Netrin is a conserved axon guidance cue that can mediate both attraction and
repulsion. We previously discovered that attractive UNC-40/DCC receptor signaling …

During the development of the nervous system, neurons encounter signals that inform their
outgrowth and polarization. Understanding how these signals combinatorially function to …

The adaptation of insect populations to insecticidal control is a continual threat to human
health and sustainable agricultural practices, but many complex genomic mechanisms …