The same genetic variant found in different individuals can cause a range of diverse
phenotypes, from no discernible clinical phenotype to severe disease, even among related …

Calvarial bone is one of the most complex sequences of developmental events in
embryology, featuring a uniquely transient, pluripotent stem cell-like population known as …

Eukaryotic initiation factor 4A-III (eIF4A3), a core helicase component of the exon junction
complex, is essential for splicing, mRNA trafficking, and nonsense-mediated decay …

Mutations in core components of the spliceosome are responsible for a group of syndromes
collectively known as spliceosomopathies. Patients exhibit microcephaly, micrognathia …

RNA helicases are involved in multiple steps of RNA metabolism to direct their roles in gene
expression, yet their functions in pluripotency control remain largely unexplored. Starting …

The exon junction complex (EJC) becomes an increasingly important regulator of early gene
expression in the central nervous system (CNS) and other tissues. The EJC is comprised of …

Mandibulofacial dysostosis (MFD) is a human congenital disorder characterized by
hypoplastic neural-crest-derived craniofacial bones often associated with outer and middle …

Embryonic stem cells (ESCs) can undergo lineage-specific differentiation, giving rise to
different cell types that constitute an organism. Although roles of transcription factors and …

Background Liver organoid technology holds great promises to be used in large-scale
population-based drug screening and in future regenerative medicine strategies. Recently …

Background As an adult tumor with the most invasion and the highest mortality rate, the
inherent heterogeneity of glioblastoma (GBM) is the main factor that causes treatment …