[HTML][HTML] Experimental and clinical evidence for modification of hepatic ischaemia–reperfusion injury by N-acetylcysteine during major liver surgery

S Jegatheeswaran, AK Siriwardena - HPB, 2011 - Elsevier
Background Hepatic ischaemia–reperfusion (I/R) injury occurs in both liver resectional
surgery and in transplantation. The biochemistry of I/R injury involves short-lived oxygen free …

The role of preconditioning and N-acetylcysteine on oxidative stress resulting from tourniquet-induced ischemia-reperfusion in arthroscopic knee surgery

K Koca, Y Yurttas, T Cayci, S Bilgic… - Journal of Trauma …, 2011 - journals.lww.com
Background: The aim of this study was to investigate the effects of ischemic preconditioning
(IPC) and N-acetylcysteine (NAC) on oxidative stress resulting from tourniquet-induced …

N‐acetylcysteine effects on genotoxic and oxidative stress parameters in cirrhotic rats with hepatopulmonary syndrome

R Vercelino, J Tieppo, AS Dias… - Basic & clinical …, 2008 - Wiley Online Library
The aim of this study was to evaluate the potential antioxidant effects of N‐acetylcysteine in
hepatopulmonary syndrome, a complication of cirrhosis, using an experimental model of …

Multidrug donor preconditioning prevents cold liver preservation and reperfusion injury

MR Moussavian, C Scheuer, M Schmidt… - … archives of surgery, 2011 - Springer
Purpose Primary graft dysfunction still represents a major challenge in liver transplantation.
We herein studied in an isolated rat liver perfusion model whether a multidrug donor …

Evaluation of potential changes in liver and lung tissue of rats in an ischemia-reperfusion injury model (modified pringle maneuver)

SH Freitas, RGS Doria, RS Bueno, WB Rocha… - PLoS …, 2017 - journals.plos.org
In surgical procedures involving the liver, such as transplantation, resection, and trauma, a
temporary occlusion of hepatic vessels may be required. This study was designed to …

Multidrug donor preconditioning protects steatotic liver grafts against ischemia-reperfusion injury

M von Heesen, K Seibert, M Hülser, C Scheuer… - The American journal of …, 2012 - Elsevier
BACKGROUND: Graft dysfunction of steatotic livers (SL) still remains a major challenge in
liver transplantation. Different mechanisms are thought to be involved in the impaired …

Short-term effects of N-acetylcysteine and ischemic preconditioning in a canine model of hepatic ischemia-reperfusion injury

J Baumann, S Ghosh, T Szakmany, G Jancso… - European Surgical …, 2008 - karger.com
Aims: We evaluated the possibility that repeated ischemic preconditioning or N-
acetylcysteine (NAC) could prevent ischemia-reperfusion injury as determined by …

[HTML][HTML] Effect of N-acetylcysteine on liver and kidney function tests after surgical bypass in obstructive jaundice: A randomized controlled trial

F Kakaei, M Fasihi, S Hashemzadeh, S Zarrintan… - Asian journal of …, 2020 - Elsevier
Background It has been shown that N-acetylcysteine may be useful in correcting
postoperative hepatic and renal function in many pathological conditions. The present study …

[HTML][HTML] N-acetylcysteine improves morphologic and functional aspects of ovarian grafts in rats

EMG Amorim, LL Damous, MCS Durando… - Acta cirurgica …, 2014 - SciELO Brasil
PURPOSE: To evaluate morphological and functional aspects of the ovarian graft in
transplanted rats treated with NAC. METHODS: Female Wistar rats, virgin, 3 to 4 months old …

Liver and lung late alterations following hepatic reperfusion associated to ischemic preconditioning or N‐acetylcysteine

MA Galhardo, CQ Júnior, PGR Navarro… - … : Official Journal of …, 2007 - Wiley Online Library
This study aimed the effect of n‐acetylcysteine or ischemic preconditioning in hepatic and
pulmonary damage after liver ischemia‐reperfusion injury. Twenty‐four male Wistar‐EPM …