New insights into the mechanism of resistance to lenvatinib and strategies for lenvatinib sensitization in hepatocellular carcinoma

FM Fan, JS Fleishman, J Chen, ZS Chen… - Drug Discovery Today, 2024 - Elsevier
Lenvatinib is a multikinase inhibitor that suppresses vascular endothelial growth factor
receptor (VEGFR), fibroblast growth factor receptor (FGFR), platelet-derived growth factor …

The current status and future of targeted-immune combination for hepatocellular carcinoma

L Hao, S Li, F Ye, H Wang, Y Zhong, X Zhang… - Frontiers in …, 2024 - frontiersin.org
Hepatocellular carcinoma (HCC) is one of the most common cancers and the third leading
cause of death worldwide. surgery, transarterial chemoembolization (TACE), systemic …

The action and resistance mechanisms of Lenvatinib in liver cancer

A Buttell, W Qiu - Molecular Carcinogenesis, 2023 - Wiley Online Library
Lenvatinib is a tyrosine kinase inhibitor that prevents the formation of new blood vessels
namely by inhibiting tyrosine kinase enzymes as the name suggests. Specifically, Lenvatinib …

Application and resistance mechanisms of lenvatinib in patients with advanced hepatocellular carcinoma

M Tao, J Han, J Shi, H Liao, K Wen… - Journal of …, 2023 - Taylor & Francis
Lenvatinib, a multitargeted tyrosine kinase inhibitor (TKI), is one of the preferred targeted
drugs for the treatment of advanced hepatocellular carcinoma (aHCC). Since the REFLECT …

Endocrine side effects in patients treated with immune checkpoint inhibitors: a narrative review

NI Profili, R Castelli, A Gidaro, A Merella… - Journal of Clinical …, 2023 - mdpi.com
Checkpoint inhibitors are monoclonal antibodies that elicit an anti-tumor response by
stimulating immune system. Their use has improved the treatment of different types of cancer …

[HTML][HTML] Emerging biomolecules for practical theranostics of liver hepatocellular carcinoma

M Hu, X Xia, L Chen, Y Jin, Z Hu, S Xia, X Yao - Annals of Hepatology, 2023 - Elsevier
Most cases of hepatocellular carcinoma (HCC) are able to be diagnosed through regular
surveillance in an identifiable patient population with chronic hepatitis B or cirrhosis …

Targeting ferroptosis in hepatocellular carcinoma

Y Mo, Z Zou, E Chen - Hepatology international, 2024 - Springer
Hepatocellular carcinoma (HCC) is a common malignant tumor with complex survival
mechanism and drug resistance, resulting in cancer-related high mortality in the world …

Management of Portal Hypertension in Patients with Hepatocellular Carcinoma on Systemic Treatment: Current Evidence and Future Perspectives

V De Gaetano, M Pallozzi, L Cerrito, F Santopaolo… - Cancers, 2024 - mdpi.com
Simple Summary Portal hypertension (PH) and hepatocellular carcinoma (HCC) are major
complications of liver cirrhosis with a detrimental impact on patient outcomes that share …

[HTML][HTML] Lenvatinib plus Immune Checkpoint Inhibitors versus Lenvatinib monotherapy as treatment for advanced hepatocellular carcinoma: a meta-analysis

X Yu, C Wei, R Cui, O Jiang - International Journal of Clinical and …, 2023 - ncbi.nlm.nih.gov
Lenvatinib, an FDA-approved first-line oral multi-kinase inhibitor for advanced
hepatocellular carcinoma (aHCC), has demonstrated promise for treatment. Nevertheless …

[HTML][HTML] Lenvatinib and immune-checkpoint inhibitors in hepatocellular carcinoma: mechanistic insights, clinical efficacy, and future perspectives

Y Chen, S Dai, C Cheng… - Journal of Hematology & …, 2024 - pmc.ncbi.nlm.nih.gov
Lenvatinib is a multi-target tyrosine kinase inhibitor widely used in the treatment of
hepatocellular carcinoma (HCC). Its primary mechanism of action involves inhibiting signal …