Pathologic vs. protective roles of hypoxia-inducible factor 1 in RPE and photoreceptors in wet vs. dry age-related macular degeneration

S Babapoor-Farrokhran, Y Qin… - Proceedings of the …, 2023 - National Acad Sciences
It has previously been reported that antioxidant vitamins can help reduce the risk of vision
loss associated with progression to advanced age-related macular degeneration (AMD), a …

Primary tumor–derived systemic nANGPTL4 inhibits metastasis

C Hübers, AA Abdul Pari, D Grieshober… - Journal of Experimental …, 2022 - rupress.org
Primary tumors and distant site metastases form a bidirectionally communicating system.
Yet, the molecular mechanisms of this crosstalk are poorly understood. Here, we identified …

Targeting hypoxia-inducible factors with 32-134D safely and effectively treats diabetic eye disease in mice

J Zhang, D Sharma, A Dinabandhu… - The Journal of …, 2023 - Am Soc Clin Investig
Many patients with diabetic eye disease respond inadequately to anti-VEGF therapies,
implicating additional vasoactive mediators in its pathogenesis. We demonstrate that levels …

Aflibercept more effectively weans patients with neovascular age-related macular degeneration off therapy compared with bevacizumab

X Cao, JC Sanchez, TP Patel, Z Yang… - The Journal of …, 2023 - Am Soc Clin Investig
BACKGROUND Studies assessing the efficacy of therapies for neovascular age-related
macular degeneration (nvAMD) have demonstrated that aflibercept may have a longer …

VEGF inhibition increases expression of HIF-regulated angiogenic genes by the RPE limiting the response of wet AMD eyes to aflibercept

D Sharma, E Lau, Y Qin, K Jee, M Rodrigues… - Proceedings of the …, 2024 - pnas.org
Neovascular age-related macular degeneration (nvAMD) is the leading cause of severe
vision loss in the elderly in the developed world. While the introduction of therapies targeting …

Vitamin A deficiency compromises the barrier function of the retinal pigment epithelium

J Moon, G Zhou, E Jankowsky, J von Lintig - PNAS nexus, 2023 - academic.oup.com
A major cause for childhood blindness worldwide is attributed to nutritional vitamin A
deficiency. Surprisingly, the molecular basis of the ensuing retinal degeneration has not …

[HTML][HTML] Correlation of serum VEGF-C, ANGPTL4, and activin A levels with frailty

H Chang, X Wang, X Gu, S Jiang, W Wang, T Wu… - Experimental …, 2024 - Elsevier
Background Secretory factors linked to lymphogenesis, such as vascular endothelial growth
factor C (VEGF-C), angiopoietin like protein 4 (ANGPTL4), and activin A (ACV-A), have been …

Renal lipid accumulation and aging linked to tubular cells injury via ANGPTL4

X Wang, H Chang, X Gu, W Han, S Mao, L Lu… - Mechanisms of Ageing …, 2024 - Elsevier
Renal tubular epithelial cells are vulnerable to stress-induced damage, including excessive
lipid accumulation and aging, with ANGPTL4 potentially playing a crucial bridging role …

ANGPTL4 promotes choroidal neovascularization and subretinal fibrosis through the endothelial‒mesenchymal transition

J Chen, Y Yang, S Su, S Zhang, J Huang… - International …, 2024 - Springer
Purpose This study aimed to investigate the possible mechanisms by which ANGPTL4 is
involved in the pathogenesis of choroidal neovascularization (CNV) and subretinal fibrosis …

血管生成素样蛋白4 通过调节成纤维细胞和内皮细胞功能影响糖尿病足进程

宋庆宏, 吴楠, 史燕, 崔洪雨, 刘飞, 刘汉冲, 周宁… - 中国组织工程研究, 2025 - cjter.com
血管生成素样蛋白4 通过调节成纤维细胞和内皮细胞功能影响糖尿病足进程 Page 1 5396|中国
组织工程研究|第29卷|第25期|2025年9月 中国组织工程研究 Chinese Journal of Tissue …