Eukaryotic nucleosomes organize chromatin by wrapping 147 bp of DNA around a histone
core particle comprising two molecules each of histone H2A, H2B, H3 and H4. The DNA …

Epigenetic mechanisms control various functions throughout the body, from cell fate
determination in development to immune responses and inflammation. Neuroinflammation …

Epigenetic regulation of gene expression has been ultimately linked to cancer development,
with posttranslational histone modifications representing attractive targets for disease …

The SET Domain Bifurcated Histone Lysine Methyltransferase 1 (SETDB1) is a prominent
member of the Suppressor of Variegation 3–9 (SUV39)-related protein lysine …

Glioblastoma (GBM) is the most common and lethal primary brain malignancy and is
characterized by a high degree of intra and intertumor cellular heterogeneity, a starkly …

Introduction: Epigenetic changes lead to aberrant gene expression in cancer. SETDB1, a
histone lysine methyltransferase plays an important role in methylation and gene silencing …

Chaetocin is a natural metabolite product with various biological activities and
pharmacological functions isolated from Chaetomium species fungi belonging to the …

Cell migration is a key process in health and disease. In the last decade an increasing
attention is given to chromatin organization in migrating cells. In various types of cells …

Epigenetic alteration by oxidative stress is vitally involved in carcinogenesis and cancer
progression. Previously, we demonstrated that oxidative stress was increased in …

Epigenetic changes that regulate chromatin structure have a major impact in genome
stabilization and maintenance of cellular homeostasis, been recently implicated in the …