Glucocorticoids are steroid hormones that regulate multiple aspects of glucose homeostasis.
Glucocorticoids promote gluconeogenesis in liver, whereas in skeletal muscle and white …

Unlike other steroid hormone receptors, the glucocorticoid receptor (GR) is not considered
an oncogene. In breast cancer, the estrogen receptor (ER) drives cell growth, proliferation …

The use of repurposing drugs that may have neoplastic and anticancer effects increases the
efficiency and decrease resistance to chemotherapy drugs through a biochemical and …

The most widespread, malignant, and deadliest type of glial tumor is glioblastoma
multiforme (GBM). Despite radiation, chemotherapy, and radical surgery, the median …

Giant cell arteritis (GCA) and polymyalgia rheumatica (PMR) are two interrelated
inflammatory diseases affecting patients above 50 years of age. Patients with GCA suffer …

Glucocorticoids (GCs) are a central component of multi-drug treatment protocols against T
and B acute lymphoblastic leukemia (ALL), which are used intensively during the remission …

Dynamic, coordinated changes in metabolic pathway activity underpin the protective and
inflammatory activity of T cells, through provision of energy and biosynthetic precursors for …

High-dose glucocorticoids (GCs) can be a useful treatment for aggressive forms of chronic
lymphocytic leukemia (CLL). However, their mechanism of action is not well understood, and …

Background/Aims: The metabolic features of cancer cells have long been acknowledged to
be altered and to provide new therapeutic opportunities. The expression of glycolytic …

Simple Summary Reduced response to glucocorticoids (GCs, such as dexamethasone,
Dex), first-line drugs employed during therapy induction, is considered a poor prognosis …