Organoids: a systematic review of ethical issues

D De Jongh, EK Massey, EM Bunnik - Stem Cell Research & Therapy, 2022 - Springer
Organoids are 3D structures grown from pluripotent stem cells derived from human tissue
and serve as in vitro miniature models of human organs. Organoids are expected to …

Tests for consciousness in humans and beyond

T Bayne, AK Seth, M Massimini, J Shepherd… - Trends in cognitive …, 2024 - cell.com
Which systems/organisms are conscious? New tests for consciousness ('C-tests') are
urgently needed. There is persisting uncertainty about when consciousness arises in human …

[HTML][HTML] Organoid intelligence (OI): the new frontier in biocomputing and intelligence-in-a-dish

L Smirnova, BS Caffo, DH Gracias, Q Huang… - Frontiers in …, 2023 - frontiersin.org
Biological computing (or biocomputing) offers potential advantages over silicon-based
computing in terms of faster decision-making, continuous learning during tasks, and greater …

[HTML][HTML] The technology, opportunities and challenges of synthetic biological intelligence

BJ Kagan, C Gyngell, T Lysaght, VM Cole… - Biotechnology …, 2023 - Elsevier
Integrating neural cultures developed through synthetic biology methods with digital
computing has enabled the early development of Synthetic Biological Intelligence (SBI) …

Consciousness in a rotor? Science and ethics of potentially conscious human cerebral organoids

F Zilio, A Lavazza - AJOB neuroscience, 2023 - Taylor & Francis
Human cerebral organoids are three-dimensional biological cultures grown in the laboratory
to mimic as closely as possible the cellular composition, structure, and function of the …

Non-human moral status: problems with phenomenal consciousness

J Shepherd - AJOB neuroscience, 2023 - Taylor & Francis
Consciousness-based approaches to non-human moral status maintain that consciousness
is necessary for (some degree or level of) moral status. While these approaches are intuitive …

Organoid intelligence (OI)–the ultimate functionality of a brain microphysiological system

L Smirnova, IEM Pantoja, T Hartung - ALTEX-Alternatives to animal …, 2023 - altex.org
Understanding brain function remains challenging as work with human and animal models
is complicated by compensatory mechanisms, while in vitro models have been too simple …

Biohybrid neural interfaces: improving the biological integration of neural implants

M Boulingre, R Portillo-Lara, RA Green - Chemical Communications, 2023 - pubs.rsc.org
Implantable neural interfaces (NIs) have emerged in the clinic as outstanding tools for the
management of a variety of neurological conditions caused by trauma or disease. However …

Interfacing brain organoids with precision medicine and machine learning

H Zheng, Y Feng, J Tang, S Ma - Cell Reports Physical Science, 2022 - cell.com
The brain is a complex organ that plays a central role in human activities. Brain organoid
modeling is an advanced technique for studying brain development, physiology, function …

Ethical, legal and social aspects of human cerebral organoids and their governance in Germany, the United Kingdom and the United States

A Pichl, R Ranisch, OA Altinok, M Antonakaki… - Frontiers in Cell and …, 2023 - frontiersin.org
Human cerebral organoids (HCOs) are model systems that enable researchers to
investigate the human brain in ways that had previously been impossible. The emergence of …