Medicinal importance, coordination chemistry with selected metals (Cu, Ag, Au) and chemosensing of thiourea derivatives. A review

E Khan, S Khan, Z Gul… - Critical Reviews in …, 2021 - Taylor & Francis
Thiourea and its derivatives are versatile compounds used in several fields of life ranging
from medicinal to chemosensor applications. In this review article, generally used …

Discovery of new anticancer thiourea-azetidine hybrids: Design, synthesis, in vitro antiproliferative, SAR, in silico molecular docking against VEGFR-2, ADMET, toxicity …

DR Parmar, JY Soni, R Guduru, RH Rayani… - Bioorganic …, 2021 - Elsevier
With the aim to discover potent and novel antitumor agents, a series of thiourea compounds
bearing 3-(4-methoxyphenyl) azetidine moiety were designed according to the essential …

Nimesulide analogues: From anti-inflammatory to antitumor agents

M Catarro, JL Serrano, SS Ramos, S Silvestre… - Bioorganic …, 2019 - Elsevier
Nimesulide is a nonsteroidal anti-inflammatory drug possessing analgesic and antipyretic
properties. This drug is considered a selective cyclooxygenase-2 (COX-2) inhibitor and …

[PDF][PDF] armacia Farmacia F

A ANDRIEŞ - 2014 - researchgate.net
Squalene is a natural dehydrotriterpenic hydrocarbon (C30H50) with six double bonds, an
intermediate for the biosynthesis of phytosterol/cholesterol in plants/animals and humans …

Experimental and computational analysis of 1-(4-chloro-3-nitrophenyl)-3-(3, 4-dichlorophenyl) thiourea

A Bielenica, S Beegum, YS Mary, YS Mary… - Journal of Molecular …, 2020 - Elsevier
This manuscript presents the computational and experimental studies of a new thiourea
derivative 1-(4-chloro-3-nitrophenyl)-3-(3, 4-dichlorophenyl) thiourea (CNDCT). Scaled …

Investigation of the reactivity properties of a thiourea derivative with anticancer activity by DFT and MD simulations

YS Mary, YS Mary, A Bielenica, S Armaković… - Journal of Molecular …, 2021 - Springer
Abstract Spectroscopic analysis of 1-(2-fluorophenyl)-3-[3-(trifluoromethyl) phenyl] thiourea
(FPTT) is reported. Experimental and theoretical analyses of FPTT, with molecular dynamics …

Design and synthesis of thiourea derivatives containing a benzo [5, 6] cyclohepta [1, 2-b] pyridine moiety as potential antitumor and anti-inflammatory agents

W Liu, J Zhou, T Zhang, H Zhu, H Qian, H Zhang… - Bioorganic & medicinal …, 2012 - Elsevier
Thiourea derivatives (6a–e) were developed and screened for antitumor and anti-
inflammatory activity. Most of the compounds exhibited growth inhibitory effects comparable …

Disubstituted thiourea derivatives and their activity on CNS: Synthesis and biological evaluation

J Stefanska, D Szulczyk, AE Koziol, B Miroslaw… - European journal of …, 2012 - Elsevier
A series of new thiourea derivatives of 1, 2, 4-triazole have been synthesized. The difference
in structures of obtained compounds are directly connected with the kind of isothiocyanate …

Design, molecular docking, and molecular dynamics of thiourea-iron (III) metal complexes as NUDT5 inhibitors for breast cancer treatment

R Ruswanto, T Nofianti, R Mardianingrum, D Kesuma - Heliyon, 2022 - cell.com
In research, anticancer agents, such as thiourea derivative compounds, and metal
complexes, such as those complexed with iron (III) metal, are often studied. The metal …

Synthesis and biological evaluation of novel indole-derived thioureas

G Sanna, S Madeddu, G Giliberti, S Piras, M Struga… - Molecules, 2018 - mdpi.com
A series of 2-(1 H-indol-3-yl) ethylthiourea derivatives were prepared by condensation of 2-
(1 H-indol-3-yl) ethanamine with appropriate aryl/alkylisothiocyanates in anhydrous media …