Intracellular metabolism is central to cell activity and function. CD4+ CD25+ regulatory T
cells (Tregs) that express the transcription factor FOXP3 play a pivotal role in the …

Abstract Alzheimer's disease (AD), the most common cause of dementia, is a complex
condition characterized by multiple pathophysiological mechanisms including amyloid‐β …

Over the past decade, antibody-mediated (humoral) rejection has been recognized as a
common cause of graft dysfunction after organ transplantation and an important determinant …

Background: The role of checkpoint axes in transplantation has been partially addressed in
animal models but not in humans. Occurrence of fulminant myocarditis with allorejection-like …

The promising outcomes of immune‐checkpoint based immunotherapies in cancer have
provided a proportional perspective ahead of exploiting similar approaches in …

Regulatory T cells (Tregs) constitute a small proportion of circulating CD4+ T cells that
function to maintain homeostasis and prevent autoimmunity. In light of their powerful …

Humoral allogeneic immunity driven by anti-HLA donor-specific antibodies and antibody-
mediated rejection (AMR) significantly impede prolonged survival of organ allografts after …

Vascularized composite allotransplantation (VCA) has become a valid therapeutic option to
restore form and function after devastating tissue loss. However, the need for high-dose …

De novo donor-specific antibody (DSA) formation is a major problem in transplantation, and
associated with long-term graft decline and loss as well as sensitization, limiting future …

Humoral rejection plays a crucial role in the chronic deterioration of kidney allografts, but
there is no effective therapeutic strategy to prevent or treat it. T follicular helper (Tfh) cells …