Treatment with proprotein convertase Subtilisin/Kexin type 9 inhibitors (PCSK9i): current evidence for expanding the paradigm?
RV Giglio, EM Muzurović, AM Patti… - Journal of …, 2023 - journals.sagepub.com
Background: Proprotein convertase subtilisin/kexin type 9 inhibitors (PCSK9i) are low-
density lipoprotein cholesterol (LDL-C)-lowering drugs that play a critical role in lipoprotein …
density lipoprotein cholesterol (LDL-C)-lowering drugs that play a critical role in lipoprotein …
[HTML][HTML] Coming back to physiology: extra hepatic functions of proprotein convertase subtilisin/kexin type 9
KD Schlüter, A Wolf, R Schreckenberg - Frontiers in Physiology, 2020 - frontiersin.org
Neuronal apoptosis regulated convertase-1 (NARC-1), now mostly known as proprotein
convertase subtilisin/kexin type 9 (PCSK9), has received a lot of attention due to the fact that …
convertase subtilisin/kexin type 9 (PCSK9), has received a lot of attention due to the fact that …
Screening of ABCG5 and ABCG8 Genes for Sitosterolemia in a Familial Hypercholesterolemia Cascade Screening Program
MT Tada, VZ Rocha, IR Lima, TGM Oliveira… - Circulation: Genomic …, 2022 - Am Heart Assoc
Background: Sitosterolemia is a rare autosomal recessive disorder caused by homozygous
or compound heterozygous variants in ABCG5/ABCG8. The disease is characterized by …
or compound heterozygous variants in ABCG5/ABCG8. The disease is characterized by …
[HTML][HTML] A novel, orally bioavailable, small-molecule inhibitor of PCSK9 with significant cholesterol-lowering properties in vivo
AK Suchowerska, G Stokman, JT Palmer… - Journal of Lipid …, 2022 - ASBMB
Proprotein convertase subtilisin kexin type 9 (PCSK9) inhibits the clearance of low-density
lipoprotein (LDL) cholesterol (LDL-C) from plasma by directly binding with the LDL receptor …
lipoprotein (LDL) cholesterol (LDL-C) from plasma by directly binding with the LDL receptor …
Anti‐PCSK 9 antibodies increase the ratios of the brain‐specific oxysterol 24S‐hydroxycholesterol to cholesterol and to 27‐hydroxycholesterol in the serum
D Lütjohann, F Stellaard, B Bölükbasi… - British Journal of …, 2021 - Wiley Online Library
Aims The serum ratios of the brain‐specific oxysterol 24S‐hydroxycholesterol (24S‐OHC) to
cholesterol and to 27‐OHC reflect brain cholesterol turnover. We studied the effect of …
cholesterol and to 27‐OHC reflect brain cholesterol turnover. We studied the effect of …
Intestinal cholesterol absorption
M Kockx, L Kritharides - Current Opinion in Lipidology, 2018 - journals.lww.com
The reduction of cardiovascular events by lowering low-density lipoprotein cholesterol (LDL-
C) levels has been unequivocally established. Although most commonly used cholesterol …
C) levels has been unequivocally established. Although most commonly used cholesterol …
Safety of ezetimibe: A systematic review and meta-analysis Appendix Figures and Tables
Y Wang - bmjmedicine.bmj.com
ABSTRACT Page 3 Structured summary 2 Provide a structured summary including, as
applicable: background; objectives; data sources; study eligibility criteria, participants, and …
applicable: background; objectives; data sources; study eligibility criteria, participants, and …