The α7β1-integrin is a transmembrane adhesion protein that connects laminin in the
extracellular matrix (ECM) with actin in skeletal muscle fibers. The α7β1-integrin is highly …

Chromatin is a unique structure of DNA and histone proteins in the cell nucleus and the site
of dynamic regulation of gene expression. Soluble factors are known to affect the chromatin …

A vast amount of work has been dedicated to the effects of shear flow and cytokines on
leukocyte transmigration. However, no studies have explored the effects of substrate …

A macrophage engulfs another cell or foreign particle in an adhesive process that often
activates myosin-II, unless the macrophage also engages “marker of self” CD47 that inhibits …

Tendons are extracellular matrix (ECM)-rich structures that mediate muscle attachments with
the skeleton, but surprisingly little is known about molecular mechanisms of attachment …

Stroke is one of the major causes of death and long-term disability, of which acute ischemic
stroke (AIS) is the most common type. Although circular RNA (circRNA) expression profiles …

Human induced pluripotent stem cell derived cardiomyocytes (hiPSC-CMs) offer
unprecedented opportunities to study inherited heart conditions in vitro, but are …

Duchenne muscular dystrophy (DMD) and limb girdle muscular dystrophy (LGMD) 2C-F
result from the loss of dystrophin and the sarcoglycans, respectively. Dystrophin, a …

The muscle tendon junction (MTJ) transmits the force generated by the muscle to the tendon
and ultimately to the bone. Tears and strains commonly occur at the MTJ where …

Mechanical forces regulate muscle development, hypertrophy, and homeostasis. Force-
transmitting structures allow mechanotransduction at the sarcolemma, cytoskeleton, and …