Anti-inflammatory effects of omega-3 fatty acids in the brain: physiological mechanisms and relevance to pharmacology

S Laye, A Nadjar, C Joffre, RP Bazinet - Pharmacological reviews, 2018 - ASPET
Classically, polyunsaturated fatty acids (PUFA) were largely thought to be relatively inert
structural components of brain, largely important for the formation of cellular membranes …

Therapeutic potential of cannabis-related drugs

SPH Alexander - Progress in Neuro-Psychopharmacology and …, 2016 - Elsevier
In this review, I will consider the dual nature of Cannabis and cannabinoids. The duality
arises from the potential and actuality of cannabinoids in the laboratory and clinic and the …

Dietary EPA‐Enriched Phospholipids Alleviate Chronic Stress and LPS‐Induced Depression‐and Anxiety‐Like Behavior by Regulating Immunity and …

CC Wang, L Du, HH Shi, L Ding… - Molecular nutrition & …, 2021 - Wiley Online Library
Scope A growing number of studies have reported the effects of eicosapentaenoic acid
(EPA) and terrestrial phospholipids on ameliorating mood disorders. Marine‐derived EPA …

Human cerebrospinal fluid fatty acid levels differ between supernatant fluid and brain-derived nanoparticle fractions, and are altered in Alzheimer's disease

AN Fonteh, M Cipolla, J Chiang, X Arakaki… - PloS one, 2014 - journals.plos.org
Background Although saturated (SAFA), monounsaturated (MUFA), and polyunsaturated
(PUFA) fatty acids are important structural components of neuronal membranes and …

Nurturing the preterm infant brain: leveraging neuroplasticity to improve neurobehavioral outcomes

D DeMaster, J Bick, U Johnson, JJ Montroy… - Pediatric …, 2019 - nature.com
An intrinsic feature of the developing brain is high susceptibility to environmental influence—
known as plasticity. Research indicates cascading disruption to neurological development …

Preclinical amyloid pathology biomarker positivity: effects on tau pathology and neurodegeneration

K Höglund, S Kern, A Zettergren… - Translational …, 2017 - nature.com
Brain autopsy and biomarker studies indicate that the pathology of Alzheimer's disease (AD)
is initiated at least 10–20 years before clinical symptoms. This provides a window of …

Nutrient sensing: another chemosensitivity of the olfactory system

AK Julliard, D Al Koborssy, DA Fadool… - Frontiers in …, 2017 - frontiersin.org
Olfaction is a major sensory modality involved in real time perception of the chemical
composition of the external environment. Olfaction favors anticipation and rapid adaptation …

CD36–A novel molecular target in the neurovascular unit

O Ioghen, L Chițoiu, M Gherghiceanu… - European Journal of …, 2021 - Wiley Online Library
CD36 is an integral membrane protein primarily known for its function as a fatty acid
transporter, yet also playing other biological roles from lipid metabolism to inflammation …

Williams syndrome, human self-domestication, and language evolution

A Niego, A Benítez-Burraco - Frontiers in psychology, 2019 - frontiersin.org
Language evolution resulted from changes in our biology, behavior, and culture. One source
of these changes might be human self-domestication. Williams syndrome (WS) is a clinical …

ApoE4 disrupts interaction of sortilin with fatty acid-binding protein 7 essential to promote lipid signaling

A Asaro, R Sinha, M Bakun, O Kalnytska… - Journal of cell …, 2021 - journals.biologists.com
Sortilin is a neuronal receptor for apolipoprotein E (apoE). Sortilin-dependent uptake of
lipidated apoE promotes conversion of polyunsaturated fatty acids (PUFA) into …