[HTML][HTML] MicroRNAs sculpt neuronal communication in a tight balance that is lost in neurological disease
KT Thomas, C Gross, GJ Bassell - Frontiers in Molecular …, 2018 - frontiersin.org
Since the discovery of the first microRNA 25 years ago, microRNAs (miRNAs) have emerged
as critical regulators of gene expression within the mammalian brain. miRNAs are small non …
as critical regulators of gene expression within the mammalian brain. miRNAs are small non …
[HTML][HTML] Lessons learned from parsing genetic risk for schizophrenia into biological pathways
The clinically heterogeneous presentation of schizophrenia is compounded by the
heterogeneity of risk factors and neurobiological correlates of the disorder. Genome-wide …
heterogeneity of risk factors and neurobiological correlates of the disorder. Genome-wide …
Serum exosomal miR-223 serves as a potential diagnostic and prognostic biomarker for dementia
H Wei, Y Xu, W Xu, Q Zhou, Q Chen, M Yang, F Feng… - Neuroscience, 2018 - Elsevier
The aims of this study were to examine the levels of serum and exosomal miR-137, miR-155
and miR-223, three neuroinflammation-related miRNAs, in dementia patients and to explore …
and miR-223, three neuroinflammation-related miRNAs, in dementia patients and to explore …
Polygenic risk score increases schizophrenia liability through cognition-relevant pathways
Cognitive deficit is thought to represent, at least in part, genetic mechanisms of risk for
schizophrenia, with recent evidence from statistical modelling of twin data suggesting direct …
schizophrenia, with recent evidence from statistical modelling of twin data suggesting direct …
Genetic and inflammatory effects on childhood trauma and cognitive functioning in patients with schizophrenia and healthy participants
Recent studies have reported a negative association between exposure to childhood
trauma, including physical neglect, and cognitive functioning in patients with schizophrenia …
trauma, including physical neglect, and cognitive functioning in patients with schizophrenia …
[HTML][HTML] Polygenic risk scores shed light on the relationship between schizophrenia and cognitive functioning: review and meta-analysis
Schizophrenia is a multifactorial disease associated with widespread cognitive impairment.
Although cognitive deficits are one of the factors most strongly associated with functional …
Although cognitive deficits are one of the factors most strongly associated with functional …
[HTML][HTML] Synergistic, long-term effects of glutamate dehydrogenase 1 deficiency and mild stress on cognitive function and mPFC gene and miRNA expression
Glutamate abnormalities in the medial prefrontal cortex (mPFC) are associated with
cognitive deficits. We previously showed that homozygous deletion of CNS glutamate …
cognitive deficits. We previously showed that homozygous deletion of CNS glutamate …
[HTML][HTML] Cognitive characterization of schizophrenia risk variants involved in synaptic transmission: evidence of CACNA1C's role in working memory
With> 100 common variants associated with schizophrenia risk, establishing their biological
significance is a priority. We sought to establish cognitive effects of risk variants at loci …
significance is a priority. We sought to establish cognitive effects of risk variants at loci …
A comprehensive review of the genetic and biological evidence supports a role for MicroRNA‐137 in the etiology of schizophrenia
K Sakamoto, JJ Crowley - … Journal of Medical Genetics Part B …, 2018 - Wiley Online Library
Since it was first associated with schizophrenia (SCZ) in a 2011 genome‐wide association
study (GWAS), there have been over 100 publications focused on MIR137, the gene …
study (GWAS), there have been over 100 publications focused on MIR137, the gene …
[HTML][HTML] A systematic review of associations between functional MRI activity and polygenic risk for schizophrenia and bipolar disorder
Z Dezhina, S Ranlund, M Kyriakopoulos… - Brain imaging and …, 2019 - Springer
Genetic factors account for up to 80% of the liability for schizophrenia (SCZ) and bipolar
disorder (BD). Genome-wide association studies have successfully identified several genes …
disorder (BD). Genome-wide association studies have successfully identified several genes …