Physical access to DNA is a highly dynamic property of chromatin that plays an essential
role in establishing and maintaining cellular identity. The organization of accessible …

IFNγ is a cytokine with important roles in tissue homeostasis, immune and inflammatory
responses and tumour immunosurveillance. Signalling by the IFNγ receptor activates the …

Blood protein extravasation through a disrupted blood–brain barrier and innate immune
activation are hallmarks of neurological diseases and emerging therapeutic targets …

Cell function and activity are regulated through integration of signaling, epigenetic,
transcriptional, and metabolic pathways. Here, we introduce INs-seq, an integrated …

Background: Cardiovascular risk in diabetes remains elevated despite glucose-lowering
therapies. We hypothesized that hyperglycemia induces trained immunity in macrophages …

Microglia are specialized brain-resident macrophages that play crucial roles in brain
development, homeostasis, and disease. However, until now, the ability to model …

Structured models of ontogenic, phenotypic and functional diversity have been instrumental
for a renewed understanding of the biology of immune cells, such as macrophages and …

Mesenchymal stromal cells (MSCs) are a subset of heterogeneous non-hematopoietic
fibroblast-like cells that can differentiate into cells of multiple lineages, such as …

Normal wound healing is a dynamic and complex multiple phase process involving
coordinated interactions between growth factors, cytokines, chemokines, and various cells …

Macrophages are crucial drivers of tumour-promoting inflammation. Tumour-associated
macrophages (TAMs) contribute to tumour progression at different levels: by promoting …