Low back pain (LBP), a prevalent and costly disease around the world, is predominantly
caused by intervertebral disc (IVD) degeneration (IDD). LBP also presents a substantial …

Intervertebral disc (IVD) degeneration is a major contributing factor for discogenic low back
pain (LBP), causing a significant global disability. The IVD consists of an inner core …

Low back pain (LBP), as a leading cause of disability, is a common musculoskeletal disorder
that results in major social and economic burdens. Recent research has identified …

Intervertebral disc (IVD) degeneration is a major cause of low back pain, a prevalent and
chronic condition that has a striking effect on quality of life. Currently, no approved …

Degeneration of the intervertebral discs (IVDs) is a major contributor to back, neck and
radicular pain. IVD degeneration is characterized by increases in levels of the …

The intervertebral disc contributes to motion, weight bearing, and flexibility of the spine, but
is susceptible to damage and morphological changes that contribute to pathology with age …

BACKGROUND: Intervertebral disc (IVD) degeneration remains a clinically important
condition for which treatment is costly and relatively ineffective. The molecular basis of …

Degenerative disc disease is a leading cause of chronic back pain in the aging population in
the world. Sinuvertebral nerve and basivertebral nerve are postulated to be associated with …

The purpose of this review was to evaluate data generated by animal models of
intervertebral disc (IVD) degeneration published in the last decade and show how this has …

Low back pain is a highly prevalent, chronic, and costly medical condition predominantly
triggered by intervertebral disc degeneration (IDD). IDD is often caused by structural and …