Adenosine receptors are major targets of caffeine, the most commonly consumed drug in the
world. There is growing evidence that they could also be promising therapeutic targets in a …

Adenosine triphosphate (ATP) is actively released in the extracellular environment in
response to tissue damage and cellular stress. Through the activation of P2X and P2Y …

Human health is under constant threat of a wide variety of dangers, both self and nonself.
The immune system is occupied with protecting the host against such dangers in order to …

Adenosine is formed inside cells or on their surface, mostly by breakdown of adenine
nucleotides. The formation of adenosine increases in different conditions of stress and …

Angiogenesis is the growth of blood vessels from the existing vasculature. The field of
angiogenesis has grown enormously in the past 30 years, with only 40 papers published in …

SARS-CoV-2 mainly invades respiratory epithelial cells by adhesion to angiotensin-
converting enzyme 2 (ACE-2) and thus, infected patients may develop mild to severe …

Plasma IL-6 is elevated after myocardial infarction (MI) and is associated with increased
morbidity and mortality. Which cardiac cell type preferentially contributes to IL-6 expression …

Adenosine has been widely associated with hypoxia of many origins, including those
associated with inflammation and tumorogenesis. A number of recent studies have …

Ischemia is a multifactorial pathology characterized by different events evolving in the time.
After ischemia a primary damage due to the early massive increase of extracellular …

Aims: A routine secondary pharmacology screen indicated that reversibly binding oral
P2Y12 receptor antagonist ticagrelor could inhibit adenosine uptake in human erythrocytes …