While the tumor suppressor functions of p53 have long been recognized, the contribution of
p53 to numerous other aspects of disease and normal life is only now being appreciated …

Inactivation of p53 is critical for the formation of most tumors. Illumination of the key function
(s) of p53 protein in protecting cells from becoming cancerous is therefore a worthy goal …

The activation of the tumor suppressor p53 facilitates the cellular response to genotoxic
stress; however, the p53 response can only be executed if its interaction with its inhibitor …

The p53 pathway has been shown to mediate cellular stress responses; p53 can initiate
DNA repair, cell-cycle arrest, senescence and, importantly, apoptosis. These responses …

The really interesting genes (RING)-finger-containing oncoprotein, Mdm2, is a promising
drug target for cancer therapy. A key Mdm2 function is to promote ubiquitylation and …

Among the human genome, p53 is one of the first tumor suppressor genes to be discovered.
It has a wide range of functions covering cell cycle control, apoptosis, genome integrity …

The importance of the p53 stress response pathway in the suppression of tumor formation is
well documented. In a previous report, a single nucleotide polymorphism (SNP309 T/G) was …

The p53 tumor suppressor gene continues to be distinguished as the most frequently
mutated gene in human cancer; this gene can be found mutated in up to 50% of human …

DNA double-strand breaks (DSB) are considered as the most deleterious DNA lesions, and
their repair is further complicated by increasing damage complexity. However, the molecular …

Kaposi's sarcoma (KS), an angioproliferative disorder, has a viral etiology and a
multifactorial pathogenesis hinged on an immune dysfunction. The disease is multifocal …