Increased use of reconstruction procedures in orthopedics, due to trauma, tumor, deformity,
degeneration and an aging population, has caused a blossom, not only in surgical …

Polystyrene (PS) has brought in vitro cell culture from its humble beginnings to the modern
era, propelling dozens of research fields along the way. This review discusses the …

The stiffness and nanotopographical characteristics of the extracellular matrix (ECM)
influence numerous developmental, physiological, and pathological processes in vivo …

The interaction of mammalian cells with nanoscale topography has proven to be an
important signaling modality in controlling cell function. Naturally occurring nanotopographic …

Tendon is a specific connective tissue composed of parallel collagen fibers. The effect of this
tissue-specific matrix orientation on stem cell differentiation has not been investigated. This …

Topography of the extracellular environment is now recognized as a major biophysical
regulator of cell behavior and function. The study of the influence of patterned substrates on …

As materials technology and the field of biomedical engineering advances, the role of
cellular mechanisms, in particular adhesive interactions with implantable devices, becomes …

Polymer sponge replication method was used in this study to prepare the macroporous
hydroxyapatite scaffolds with interconnected oval shaped pores of 100–300μm with pore …

The need to control the adhesion of cells to material surfaces plays an important role in
determining the design of biomaterial substrates for biotechnology and tissue-engineering …

Cellular behavior can be influenced by the chemical and physical surface characteristics of
biomedical substrates. To understand the relationships between various topographical …