Alzheimer's disease (AD) differentially and specifically affects brain regions and neuronal
cell types in a predictable pattern. Damage to the brain appears to spread and worsens with …

Alzheimer's disease (AD) is characterized by specific alterations of brain DNA methylation
(DNAm) patterns. Age and sex, two major risk factors for AD, are also known to largely affect …

Proteomic studies of human Alzheimer's disease brain tissue have potential to identify
protein changes that drive disease, and to identify new drug targets. Here, we analyse 38 …

Background: Metagenomic data support an association between certain bacterial strains
and Alzheimer's disease (AD), but their functional dynamics remain elusive. Objective: To …

Accumulation of phosphorylated tau is a key pathological feature of Alzheimer's disease.
Phosphorylated tau accumulation causes synaptic impairment, neuronal dysfunction and …

Amyloid plaques contain many proteins in addition to beta amyloid (Aβ). Previous studies
examining plaque-associated proteins have shown these additional proteins are important; …

Complement is involved in developmental synaptic pruning and pathological synapse loss
in Alzheimer's disease. It is posited that C1 binding initiates complement activation on …

Alzheimer's disease (AD) is an unremitting neurodegenerative disorder characterized by
cerebral amyloid-β (Aβ) accumulation and gradual decline in cognitive function. Changes in …

Alzheimer's disease (AD) is the most common cause of age-related neurodegeneration and
dementia, and there are no available treatments with proven disease-modifying actions. It is …

Epigenome-wide association studies of Alzheimer's disease have highlighted
neuropathology-associated DNA methylation differences, although existing studies have …