RNA is a unique bio-macromolecule that can both record genetic information and perform
biological functions in a variety of molecular processes, including transcription, splicing …

RNA is structurally very flexible, which provides the basis for its functional diversity. An RNA
molecule can often adopt different conformations, which enables the regulation of its …

The expression of genes, both coding and noncoding, can be significantly influenced by
RNA structural features of their corresponding transcripts. There is by now mounting …

Proper gene expression is essential for the survival of every cell. Once thought to be a
passive transporter of genetic information, RNA has recently emerged as a key player in …

Twenty-two years after their discovery as ribozymes, the self-splicing group I introns are
finally disclosing their architecture at the atomic level. The crystal structures of three group I …

Many RNA-binding proteins help RNAs to fold via their RNA chaperone activity. This term
has been used widely without accounting for the diversity of the observed reactions, which …

Compact but non-native intermediates have been implicated in the hierarchical folding of
several large RNAs, but there is little information on their structure. In this article …

Intrinsic events during RNA folding include conformational search and metal ion binding.
Several experimentally testable models have been proposed to explain how large …

Group II introns are large ribozymes that act as self-splicing and retrotransposable RNA
molecules. They are of great interest because of their potential evolutionary relationship to …

RNA folding is the most essential process underlying RNA function. While significant
progress has been made in understanding the forces driving RNA folding in vitro, exploring …