More than half a century ago researchers thought that d-amino acids had a minor function
compared to l-enantiomers in biological processes. Many evidences have shown that d …

d-amino acids have been detected in a variety of peptides synthesized by animal cells.
These include opiate and antimicrobial peptides from amphibian skin, neuropeptides from …

D-amino acid oxidase (DAO) is a flavoenzyme that metabolizes certain D-amino acids,
notably the endogenous N-methyl D-aspartate receptor (NMDAR) co-agonist, D-serine. As …

d-Amino acid oxidase (DAAO) catalyzes the oxidation of d-amino acids including d-serine, a
full agonist at the glycine site of the NMDA receptor. A series of benzo [d] isoxazol-3-ol …

Background: Observations that antagonists of the N-methyl-d-aspartate (NMDA) receptor of
glutamatergic neurons can mimic symptoms of schizophrenia have raised the hope that …

Cognitive impairment is one of the most common complications associated with chronic
pain. Almost 20% of chronic pain patients suffer from cognitive impairment, which may …

Numerous studies over the last several years have shown that d-amino acids, especially d-
serine, have been related to brain and neurological disorders. Acknowledged neurological …

The endogenous amino acids serine and aspartate occur at high concentrations in free D-
form in mammalian organs, including the central nervous system and endocrine glands. D …

OBJECTIVES: Based on the hypothesis of NMDA receptor hypofunction in schizophrenia,
plasma glycine, l-serine, and d-serine levels have been studied, since they could serve as …

Besides d-serine, another d-amino acid with endogenous occurrence in the mammalian
brain, d-aspartate, has been recently shown to influence NMDA receptor (NMDAR) …