The proteome, or collection of proteoforms expressed in a biological system, is dynamic and
heterogeneous. As our appreciation for the complexity of the proteome has evolved, so have …

Mapping the ligandability or potential druggability of all proteins in the human proteome is a
central goal of mass spectrometry-based covalent chemoproteomics. Achieving this …

Mass spectrometry-based sample multiplexing with isobaric tags permits the development of
high-throughput and precise quantitative biological assays with proteome-wide coverage …

Cysteine chemoproteomic screening platforms are widely utilized for chemical probe and
drug discovery campaigns. Chemoproteomic compound screens, which use a mass …

Protein homeostasis is tightly regulated, with damaged or misfolded proteins quickly
eliminated by the proteasome and autophagosome pathways. By co-opting these …

Targeted proteomics has been playing an increasingly important role in hypothesis-driven
protein research and clinical biomarker discovery. We previously created a workflow …

Single-cell proteomics is a powerful approach to precisely profile protein landscapes within
individual cells toward a comprehensive understanding of proteomic functions and tissue …

Mapping the ligandability or potential druggability of all proteins in the human proteome is a
central goal of mass spectrometry-based chemoproteomics. Achieving this ambitious …

In this study, we analyzed the combination of affinity purification mass spectrometry (AP-MS)
with high-field asymmetric waveform ion mobility spectrometry (FAIMS), integrated between …

Hardware changes introduced on the Orbitrap Ascend MultiOmics Tribrid MS include dual
ion routing multipoles (IRMs) that can enable parallelized accumulation, dissociation, and …