[HTML][HTML] Clozapine-associated pericarditis and pancreatitis in children and adolescents: A systematic literature review and pharmacovigilance study using the …

R de Filippis, C De las Cuevas, EJ Sanz… - Schizophrenia …, 2023 - Elsevier
Background The literature has paid very little attention to pericarditis, pericardial effusion
and pancreatitis during clozapine treatment in children and adolescents. Methods Cases of …

Umbrella Review: Early-Onset Psychosis: Atlas of the Meta-Analytical Evidence

GS de Pablo, V Rodriguez, F Besana… - Journal of the American …, 2024 - Elsevier
Objective Early-onset psychosis (EOP) refers to the development of psychosis before the
age of 18 years. We aimed to summarize for the first time the meta-analytical evidence in the …

Rethinking clozapine: lights and shadows of a revolutionary drug

L Dell'Osso, C Bonelli, B Nardi, F Giovannoni… - Brain Sciences, 2024 - mdpi.com
The current literature globally highlights the efficacy of Clozapine in several psychiatric
disorders all over the world, with an FDA indication for reducing the risk of repeated suicidal …

Clozapine-induced myocarditis in children and adolescents: a pharmacovigilance study using VigiBase and a systematic literature review

C De Las Cuevas, M Arrojo-Romero… - Expert Opinion on …, 2022 - Taylor & Francis
Introduction Clozapine-induced myocarditis in children (age≤ 18 yo) was studied from a
PubMed search (18 July 2022)(9 cases) and from the World Health Organization's …

CLEAR–clozapine in early psychosis: study protocol for a multi-centre, randomised controlled trial of clozapine vs other antipsychotics for young people with treatment …

C Casetta, P Santosh, R Bayley, J Bisson, S Byford… - BMC psychiatry, 2024 - Springer
Background Clozapine is an antipsychotic drug with unique efficacy, and it is the only
recommended treatment for treatment-resistant schizophrenia (TRS: failure to respond to at …

Identification and treatment of individuals with childhood-onset and early-onset schizophrenia

CU Correll, C Arango, B Fagerlund, S Galderisi… - European …, 2024 - Elsevier
Approximately 8% of patients with schizophrenia are diagnosed before age 18, and 18%
experience their first symptoms before age 18. This narrative review explores the …

Investigating amplitude of low-frequency fluctuation and possible links with cognitive impairment in childhood and adolescence onset schizophrenia: A correlation …

Y Liang, R Shao, Y Xia, Y Li, S Guo - Frontiers in Psychiatry, 2024 - frontiersin.org
Background Cognitive impairment (CI) is a distinctive characteristic of schizophrenia, with
evidence suggesting that childhood and adolescence onset schizophrenia (CAOS) …

Clozapine treatment for aggressive behaviors in youths with neurodevelopmental disorders

S Berloffa, G Masi, F Falcone, V Simonelli… - Journal of child and …, 2024 - liebertpub.com
Objectives: The aim of this study was to assess effectiveness and tolerability of Clozapine in
the treatment of aggression in youth with Neurodevelopmental Disorders. Methods: Patients …

Survey on barriers to psychiatrists' use of clozapine for young people in Scotland and suggestions for reducing these

G Walker, J Lang, H Smith - PLOS ONE, 2024 - journals.plos.org
Introduction The Mental Welfare Commission for Scotland published a report into the death
of a young person, with recommendations for the Royal College of Psychiatry in Scotland …

Clozapine, relapse, and adverse events: a 10-year electronic cohort study in Canada

L Balbuena, S Halayka, A Lee, AG Ahmed… - The British Journal of …, 2024 - cambridge.org
BackgroundClozapine is the most effective medication for treatment-resistant psychoses, but
the balance of benefits and risks is understudied in real-world settings. AimsTo examine the …