Natural products, with remarkable chemical diversity, have been extensively investigated for
their anticancer potential for more than a half-century. The collective efforts of the community …

Tumor cells can “hijack” chemokine networks to support tumor progression. In this context,
the CC chemokine ligand 5/CC chemokine receptor type 5 (CCL5/CCR5) axis is gaining …

Macrophages are crucial drivers of tumour-promoting inflammation. Tumour-associated
macrophages (TAMs) contribute to tumour progression at different levels: by promoting …

Transcription factors are involved in a large number of human diseases such as cancers for
which they account for about 20% of all oncogenes identified so far. For long time, with the …

Purpose This multicenter study, to our knowledge, is the first phase III trial to compare
trabectedin versus dacarbazine in patients with advanced liposarcoma or leiomyosarcoma …

Diversity and plasticity are hallmarks of cells of the monocyte-macrophage lineage. In
response to IFNs, Toll-like receptor engagement, or IL-4/IL-13 signaling, macrophages …

Tumor-associated macrophages (TAMs), representing most of the leukocyte population in
solid tumors, demonstrate great phenotypic heterogeneity and diverse functional capabilities …

There is widespread interest in macrophages as a therapeutic target in cancer. Here, we
demonstrate that trabectedin, a recently approved chemotherapeutic agent, induces rapid …

Macrophages play a key role in defending against foreign pathogens, healing wounds, and
regulating tissue homeostasis. Driving this versatility is their phenotypic plasticity, which …

Chronic inflammation is a well-recognized tumor-enabling capability, which allows nascent
tumors to escape immunosurveillance. A number of soluble and cellular inflammatory …