Over the past decade, a growing number of studies have revealed that progressive changes
to epigenetic information accompany aging in both dividing and nondividing cells …

Post-translational modifications (PTM) decorate proteins to provide functional heterogeneity
to an existing proteome. The large number of known PTMs highlights the many ways that …

Increased glucose production and reduced hepatic glycogen storage contribute to metabolic
abnormalities in diabetes. Irisin, a newly identified myokine, induces the browning of white …

Saccharomyces cerevisiae has directly or indirectly contributed to the identification of
arguably more mammalian genes that affect aging than any other model organism. Aging in …

Occurrence of hyperglycemia upon infection is associated with worse clinical outcome in
COVID-19 patients. However, it is still unknown whether SARS-CoV-2 directly triggers …

Brown adipose tissue (BAT) can disperse stored energy as heat. Promoting BAT-like
features in white adipose (WAT) is an attractive, if elusive, therapeutic approach to staunch …

It is becoming increasingly clear that cellular signalling and metabolism are not just separate
entities but rather are tightly linked. Although nutrient metabolism is known to be regulated …

We review mechanisms that regulate production of glucose by the liver, focusing on areas of
budding consensus, and endeavoring to provide a candid assessment of lingering …

Lysine acetylation regulates many eukaryotic cellular processes, but its function in
prokaryotes is largely unknown. We demonstrated that central metabolism enzymes in …

Cells undergoing developmental processes are characterized by persistent non-genetic
alterations in chromatin, termed epigenetic changes, represented by distinct patterns of DNA …