Alpha-lipoic acid (LA) has become a common ingredient in multivitamin formulas, anti-aging
supplements, and even pet food. It is well-defined as a therapy for preventing diabetic …

Introduction: Neuropathy is a serious complication of diabetes. Its management focuses on
glycaemic control, multifactorial cardiovascular risk intervention, pathogenesis-oriented …

Alzheimer's disease (AD) is a progressive neurodegenerative disorder that destroys patient
memory and cognition, communication ability with the social environment and the ability to …

Alzheimer's disease (AD) is a progressive neurodegenerative disorder, characterized by
deposition of amyloid plaques and neurofibrillary tangles, as well as microglial and …

In the past century, noncommunicable diseases have surpassed infectious diseases as the
principal cause of sickness and death, worldwide. Trillions of commensal microbes live in …

抄録 The role of R-α-lipoic acid as a cofactor (lipoyllysine) in mitochondrial energy
metabolism is well established. Lipoic acid non-covalently bound and exogenously …

The endogenous disulfide α-lipoic acid (LA) is an essential mitochondrial co-factor. In
addition, LA and its reduced counterpart dihydro lipoic acid form a potent redox couple with …

Alpha‐lipoic acid (ALA) has been used as a dietary supplement at different doses in patients
with diabetes mellitus type 2 (T2DM) due to its antioxidant, anti‐inflammatory, and …

Pathological deterioration of mitochondrial function is increasingly linked with multiple
degenerative illnesses as a mediator of a wide range of neurologic and age-related chronic …

Objectives: α-lipoic acid (ALA) is a natural antioxidant which acts as a cofactor of
bioenergetic mitochondrial enzymes. Along with its mitochondrial action, ALA and its …