Exercise and muscle contractions create a powerful stimulus for structural remodeling of the
vasculature. An increase in flow velocity through a vessel increases shear stress, a major …

Maximal oxygen uptake is a physiological characteristic bounded by the parametric limits of
the Fick equation:(left ventricular (LV) end‐diastolic volume− LV end‐systolic volume)× heart …

Cumulative mtDNA damage occurs in aging animals, and mtDNA mutations are reported to
accelerate aging in mice. We determined whether aging results in increased DNA oxidative …

Background. Lower ambulatory performance with aging may be related to a reduced
oxidative capacity within skeletal muscle. This study examined the associations between …

Changing arterial oxygen content (C) has a highly sensitive influence on the rate of
peripheral locomotor muscle fatigue development. We examined the effects of C on exercise …

Skeletal muscle blood flow is closely coupled to metabolic demand, and its regulation is
believed to be mainly the result of the interplay of neural vasoconstrictor activity and locally …

Severe‐intensity constant‐work‐rate exercise results in the attainment of maximal oxygen
uptake, but the muscle metabolic milieu at the limit of tolerance (Tlim) for such exercise …

Non‐Technical Summary Reduced atmospheric O2 availability (hypoxia) impairs muscle
oxidative energy production and exercise tolerance. We show that dietary supplementation …

The dynamic biochemical and mechanical environment around blood vessels during muscle
activity generates powerful stimuli for vascular remodelling. Ultimately, this must lead to a …

Molecular oxygen (O2) is a vital element in human survival and plays a major role in a
diverse range of biological and physiological processes. Although normobaric hyperoxia …