Discussion of the antibody repertoire usually emphasizes diversity, but a conspicuous
feature of the light chain repertoire is its lack of diversity. The diversity of reported allelic …

Immunoglobulins (Igs), as one of the hallmarks of adaptive immunity, first arose
approximately 500 million years ago with the emergence of jawed vertebrates. Two events …

Immunogenomic loci remain poorly understood because of their genetic complexity and
size. Here, we report the de novo assembly of a cattle genome and provide a detailed …

Vaccines are one of the most important tools available to prevent and reduce the incidence
of infectious diseases in cattle. Despite their availability and widespread use to combat …

Teleost B cells are primitive lymphocytes with both innate and adaptive immune functions.
However, the heterogeneity and differentiation trajectory of teleost B cells remain largely …

The antibody repertoire of Bos taurus is characterized by a subset of variable heavy (VH)
chain regions with ultralong third complementarity determining regions (CDR3) which …

The generation of broadly neutralizing antibodies (bnAbs) to conserved epitopes on HIV
Envelope (Env) is one of the cornerstones of HIV vaccine research. The animal models …

The utility of X-ray crystal structures determined under ambient-temperature conditions is
becoming increasingly recognized. Such experiments can allow protein dynamics to be …

The V (D) J recombination process rearranges the variable (V), diversity (D), and joining (J)
genes in the immunoglobulin (IG) loci to generate antibody repertoires. Annotation of these …

An important challenge in vaccine development is to figure out why a vaccine succeeds in
some individuals and fails in others. Although antibody repertoires hold the key to answering …