Many lines of evidence, including epidemiologic data and extensive clinical and
experimental studies, indicate that early life events play a powerful role in influencing later …

Osteoporosis is becoming an increasingly important public health issue, and effective
treatments to prevent fragility fractures are available. Osteoporosis imaging is of critical …

Background Vitamin D insufficiency is common in women of childbearing age and
increasing evidence suggests that the risk of osteoporotic fracture in adulthood could be …

Puberty is a defining phase of human development where growth ends and the ability to
reproduce begins. An understanding of the events leading up to puberty highlights the fact …

Abstract The British Association for Psychopharmacology guidelines specify the scope and
target of treatment for bipolar disorder. The second version, like the first, is based explicitly …

We estimated peak bone mass (PBM) in 615 women and 527 men aged 16 to 40 years
using longitudinal data from the Canadian Multicentre Osteoporosis Study (CaMos) …

Recent findings suggest that maternal vitamin D insufficiency during pregnancy has
consequences for the offspring's bone health in later life. To investigate whether maternal …

Objectives To assess the effectiveness of calcium supplementation for improving bone
mineral density in healthy children and to determine if any effect is modified by other factors …

Background Results of randomised controlled trials (RCTs) of vitamin D supplementation to
improve bone density in children are inconsistent. Objectives To determine the effectiveness …

Background Very-low-birth-weight (VLBW,< 1,500 g) infants have compromised bone mass
accrual during childhood, but it is unclear whether this results in subnormal peak bone mass …