Cystic kidneys are common causes of end-stage renal disease, both in children and in
adults. Autosomal dominant polycystic kidney disease (ADPKD) and autosomal recessive …

This review aims to assist in the categorization of inherited, developmental, and acquired
cystic disease of the kidney as well as to provide a pertinent, up-to-date bibliography. The …

Organoids serve as a novel tool for disease modeling in three-dimensional multicellular
contexts. Static organoids, however, lack the requisite biophysical microenvironment such …

OBJECTIVE—The etiology of type 2 diabetes often involves diet-induced obesity (DIO),
which is associated with elevated plasma fatty acids and lipoprotein associated triglycerides …

Although many vertebrate organs, such as kidneys, lungs and liver, are composed of
epithelial tubules, little is known of the mechanisms that establish the length or diameter of …

Autosomal recessive polycystic kidney disease (ARPKD) is a hepatorenal fibrocystic
disorder that is characterized by enlarged kidneys with progressive loss of renal function …

Bile duct epithelial cells, also known as cholangiocytes, regulate the composition of bile and
its flow. Acquired, congenital and genetic dysfunctions in these cells give rise to a set of …

Background & Aims: Cholangiocytes have primary cilia extending from the apical plasma
membrane into the ductal lumen. While the physiologic significance of cholangiocyte cilia is …

Cystic kidney diseases are among the most frequent lethal genetic diseases. Positional
cloning of novel cystic kidney disease genes revealed that their products (cystoproteins) are …

Autosomal recessive polycystic kidney disease (ARPKD) is an important cause of chronic
kidney disease in children. The care of ARPKD patients has traditionally been the realm of …