The red flour beetle Tribolium castaneum has emerged as an important insect model system
for a variety of topics. With respect to studying gene function, it is second only to the vinegar …

RNA interference (RNAi) has emerged as a powerful tool for knocking-down gene function
in diverse taxa including arthropods for both basic biological research and application in …

Genetic screens are powerful tools to identify the genes required for a given biological
process. However, for technical reasons, comprehensive screens have been restricted to …

Abstract The iBeetle-Base (http://ibeetle-base. uni-goettingen. de) makes available
annotations of RNAi phenotypes, which were gathered in a large scale RNAi screen in the …

Oscillatory and sequential processes have been implicated in the spatial patterning of many
embryonic tissues. For example, molecular clocks delimit segmental boundaries in …

In animals, body axis patterning is based on the concentration-dependent interpretation of
graded morphogen signals, which enables correct positioning of the anatomical structures …

Gene expression has been employed for homologizing body regions across bilateria. The
molecular comparison of vertebrate and fly brains has led to a number of disputed homology …

The Wnt family of secreted proteins has been proposed to play a conserved role in early
specification of the bilaterian anteroposterior (A/P) axis. This hypothesis is based …

BACKGROUND Epidermal growth factor receptor (EGFR), zinc finger homeodomain‐2 (zfh‐
2), Abdominal‐A (Abd‐A), and Abdominal‐B (Abd‐B) regulate the growth and development …

The development of the oral pole in cnidarians and the posterior pole in bilaterians is
regulated by canonical Wnt signaling, whereas a set of transcription factors, including Six3/6 …