Simple Summary Since the targeting of a single pro-angiogenic factor fails to improve
oncological disease outcome, significant efforts have been made to identify new pro …

Semaphorins are membrane-bound or diffusible factors that regulate key cellular functions
and are involved in cell–cell communication. Most of the effects of semaphorins are …

Cell-cell communication is pivotal to guide embryo development, as well as to maintain adult
tissues homeostasis and control immune response. Among extracellular factors responsible …

The semaphorins were initially characterized as axon guidance factors, but have
subsequently been implicated also in the regulation of immune responses, angiogenesis …

Semaphorins are regulatory molecules that are linked to the modulation of several cancer
processes, such as angiogenesis, cancer cell invasiveness and metastasis, tumor growth …

The axonal guidance molecules, semaphorins, have been described to function both
physiologically and pathologically outside of the nervous system. In this review, we focus on …

Semaphorins are a large family of secreted, transmembrane, or GPI-anchored proteins
initially identified as axon guidance cues signaling through their receptors, neuropilins, and …

Recent studies have shown that peripheral nerves play an important role in the progression
of breast cancer. Breast cancer cells (BCCs) promote local peripheral nerve growth and …

Postpartum mammary gland involution is a tissue remodeling event that occurs in all
mammals in the absence of nursing or after weaning to return the gland to the pre-pregnant …

Ovarian cancer is characterized by early transcoelomic metastatic spread via the peritoneal
fluid, where tumor cell spheroids (TU), tumor-associated T cells (TAT), and macrophages …