The roles of Gβγ and Gα in gating and regulation of GIRK channels
N Dascal, U Kahanovitch - International review of neurobiology, 2015 - Elsevier
Abstract G protein-gated K+(GIRK, or Kir3) channels mediate inhibitory neurotransmission
via G protein-coupled receptors (GPCRs) in heart and brain. The signaling cascade involves …
via G protein-coupled receptors (GPCRs) in heart and brain. The signaling cascade involves …
Selective Inhibition of Pulmonary Vein Excitability by Constitutively Active GIRK Channels Blockade in Rats
I Findlay, C Pasqualin, A Yu, V Maupoil… - International Journal of …, 2023 - mdpi.com
Pulmonary veins (PV) are the main source of ectopy, triggering atrial fibrillation. This study
investigated the roles of G protein-coupled inwardly rectifying potassium (GIRK) channels in …
investigated the roles of G protein-coupled inwardly rectifying potassium (GIRK) channels in …
Muscarinic receptor control of pyramidal neuron membrane potential in the medial prefrontal cortex (mPFC) in rats
P Kurowski, M Gawlak, P Szulczyk - Neuroscience, 2015 - Elsevier
Damage to the cholinergic input to the prefrontal cortex has been implicated in
neuropsychiatric disorders. Cholinergic endings release acetylcholine, which activates …
neuropsychiatric disorders. Cholinergic endings release acetylcholine, which activates …
A quantitative model of the GIRK1/2 channel reveals that its basal and evoked activities are controlled by unequal stoichiometry of Gα and Gβγ
D Yakubovich, S Berlin, U Kahanovitch… - PLOS Computational …, 2015 - journals.plos.org
G protein-gated K+ channels (GIRK; Kir3), activated by Gβγ subunits derived from Gi/o
proteins, regulate heartbeat and neuronal excitability and plasticity. Both neurotransmitter …
proteins, regulate heartbeat and neuronal excitability and plasticity. Both neurotransmitter …
Recruitment of Gβγ controls the basal activity of G‐protein coupled inwardly rectifying potassium (GIRK) channels: crucial role of distal C terminus of GIRK1
U Kahanovitch, V Tsemakhovich, S Berlin… - The Journal of …, 2014 - Wiley Online Library
Key points The G‐protein coupled inwardly rectifying potassium (GIRK) channel is an
important mediator of neurotransmission via Gβγ subunit of the heterotrimeric Gi/o protein …
important mediator of neurotransmission via Gβγ subunit of the heterotrimeric Gi/o protein …
Mutual action by Gγ and Gβ for optimal activation of GIRK channels in a channel subunit-specific manner
G Tabak, T Keren-Raifman, U Kahanovitch, N Dascal - Scientific reports, 2019 - nature.com
The tetrameric G protein-gated K+ channels (GIRKs) mediate inhibitory effects of
neurotransmitters that activate Gi/o-coupled receptors. GIRKs are activated by binding of the …
neurotransmitters that activate Gi/o-coupled receptors. GIRKs are activated by binding of the …
Tethered protein display identifies a novel Kir3. 2 (GIRK2) regulator from protein scaffold libraries
SN Bagriantsev, FC Chatelain, KA Clark… - ACS Chemical …, 2014 - ACS Publications
Use of randomized peptide libraries to evolve molecules with new functions provides a
means for developing novel regulators of protein activity. Despite the demonstrated power of …
means for developing novel regulators of protein activity. Despite the demonstrated power of …
NCI-H295R cell line as in vitro model of hyperaldosteronism lacks functional KCNJ5 (GIRK4; Kir3. 4) channels
As a major cause of aldosterone producing adenomas, numerous gain-of-function mutations
in the KCNJ5 gene (encoding the K+ channel subunit GIRK4) have been identified. The …
in the KCNJ5 gene (encoding the K+ channel subunit GIRK4) have been identified. The …
Physiological contribution and molecular details of GIRK-dependent signaling in the heart
AD Anderson - 2020 - search.proquest.com
Activation of parasympathetic signaling to the heart results in a slowing of heart rate (HR)
and an increase in heart rate variability (HRV). Perturbations in parasympathetic signaling to …
and an increase in heart rate variability (HRV). Perturbations in parasympathetic signaling to …