Targeting drugs to tumours using cell membrane-coated nanoparticles

RH Fang, W Gao, L Zhang - Nature Reviews Clinical Oncology, 2023 - nature.com
Traditional cancer therapeutics, such as chemotherapies, are often limited by their non-
specific nature, causing harm to non-malignant tissues. Over the past several decades …

CD4+ T cells in cancer

DE Speiser, O Chijioke, K Schaeuble, C Münz - Nature cancer, 2023 - nature.com
Cancer immunology and immunotherapy are driving forces of research and development in
oncology, mostly focusing on CD8+ T cells and the tumor microenvironment. Recent …

Therapeutic cancer vaccines

M Saxena, SH van der Burg, CJM Melief… - Nature Reviews …, 2021 - nature.com
Therapeutic cancer vaccines have undergone a resurgence in the past decade. A better
understanding of the breadth of tumour-associated antigens, the native immune response …

[HTML][HTML] Turning cold tumors into hot tumors by improving T-cell infiltration

YT Liu, ZJ Sun - Theranostics, 2021 - ncbi.nlm.nih.gov
Immunotherapy, represented by immune checkpoint inhibitors (ICIs), has greatly improved
the clinical efficacy of malignant tumor therapy. ICI-mediated antitumor responses depend …

Bacterial cytoplasmic membranes synergistically enhance the antitumor activity of autologous cancer vaccines

L Chen, H Qin, R Zhao, X Zhao, L Lin, Y Chen… - Science translational …, 2021 - science.org
Cancer vaccines based on resected tumors from patients have gained great interest as an
individualized cancer treatment strategy. However, eliciting a robust therapeutic effect with …

CD4+ T cell help in cancer immunology and immunotherapy

J Borst, T Ahrends, N Bąbała, CJM Melief… - Nature Reviews …, 2018 - nature.com
Cancer immunotherapy aims to promote the activity of cytotoxic T lymphocytes (CTLs) within
a tumour, assist the priming of tumour-specific CTLs in lymphoid organs and establish …

[HTML][HTML] Turning the corner on therapeutic cancer vaccines

RE Hollingsworth, K Jansen - npj Vaccines, 2019 - nature.com
Recent advances in several areas are rekindling interest and enabling progress in the
development of therapeutic cancer vaccines. These advances have been made in target …

Engineered cell‐membrane‐coated nanoparticles directly present tumor antigens to promote anticancer immunity

Y Jiang, N Krishnan, J Zhou, S Chekuri… - Advanced …, 2020 - Wiley Online Library
The recent success of immunotherapies has highlighted the power of leveraging the
immune system in the fight against cancer. In order for most immune‐based therapies to …

Recent advances in overcoming barriers to cell‐based delivery systems for cancer immunotherapy

Y Ding, Y Wang, Q Hu - Exploration, 2022 - Wiley Online Library
Immunotherapy strategies that use cell‐based delivery systems have sparked much interest
in the treatment of malignancies, owing to their high biocompatibility, excellent tumor …

[HTML][HTML] Nanocarriers based on bacterial membrane materials for cancer vaccine delivery

X Zhao, R Zhao, G Nie - Nature protocols, 2022 - nature.com
Here we present a protocol for the construction and use of two types of nanocarrier based on
bacterial membrane materials for cancer vaccine delivery. Cancer vaccines induce tumor …