Neutrophils (polymorphonuclear cells; PMNs) form a first line of defense against pathogens
and are therefore an important component of the innate immune response. As a result of …

In the past, inflammation has been associated with infections and with the immune system.
But more recent evidence suggests that a much broader range of diseases have telltale …

Corticosteroids have been shown to exert beneficial effects in the treatment of acute
myocardial infarction, but the precise mechanisms underlying their protective effects are …

Most leukocytes can roll along the walls of venules at low shear stress (1 dyn cm− 2), but
neutrophils have the ability to roll at tenfold higher shear stress in microvessels in vivo,. The …

In inflammation, neutrophils roll along the endothelial wall of postcapillary venules and
sample inflammatory signals. Neutrophil activation is required to generate β2 integrin bonds …

Leukocyte recruitment requires leukocyte rolling, activation, firm adhesion, and
transmigration. Injection of the proinflammatory cytokine TNF-alpha induces expression of E …

The physiologic role of L-selectin shedding is unknown. Here, we investigate the effect of L-
selectin shedding on firm adhesion and transmigration. In a tumor necrosis factor α–induced …

We propose a cell detection and tracking solution using image-level sets computed via
threshold decomposition. In contrast to existing methods where manual initialization is …

Leukocyte recruitment to sites of inflammation is initiated by their tethering and rolling on the
activated endothelium under flow. Even though the fast kinetics and high tensile strength of …

Studies with neutralizing antibodies have indicated roles for platelet-endothelial cell
adhesion molecule-1 (PECAM-1) in leukocyte migration through the endothelium and the …