Omics techniques generate large, multidimensional data that are amenable to analysis by
new informatics approaches alongside conventional statistical methods. Systems theories …

Glucose and fatty acids are the major sources of energy for human body. Cholesterol, the
most abundant sterol in mammals, is a key component of cell membranes although it does …

Increased blood lipid levels are heritable risk factors of cardiovascular disease with varied
prevalence worldwide owing to different dietary patterns and medication use. Despite …

To elucidate the genetics of coronary artery disease (CAD) in the Japanese population, we
conducted a large-scale genome-wide association study of 168,228 individuals of Japanese …

Clinical laboratory tests are a critical component of the continuum of care. We evaluate the
genetic basis of 35 blood and urine laboratory measurements in the UK Biobank (n …

Abstract The Million Veteran Program (MVP) was established in 2011 as a national research
initiative to determine how genetic variation influences the health of US military veterans …

Early genome-wide association studies (GWASs) led to the surprising discovery that, for
typical complex traits, most of the heritability is due to huge numbers of common variants …

Importance Monogenic familial hypercholesterolemia (FH) is associated with lifelong
elevations in low-density lipoprotein cholesterol (LDL-C) levels and increased risk of …

We screened variants on an exome-focused genotyping array in> 300,000 participants
(replication in> 280,000 participants) and identified 444 independent variants in 250 loci …

A genome-wide association study (GWAS) of 94,674 ancestrally diverse Kaiser Permanente
members using 478,866 longitudinal electronic health record (EHR)-derived measurements …