Urease is a kind of enzyme which could be found in various bacteria, fungi, plants, and
algae, which can quickly catalyze the hydrolysis of urea into ammonia and carbon dioxide …

Urease is an attractive drug target for designing anti-infective agents against pathogens
such as Helicobacter pylori, Proteus mirabilis, and Ureaplasma urealyticum. In the past …

The present article describes the design, synthesis, in vitro urease inhibition, and in silico
molecular docking studies of a novel series of nitrothiazolacetamide conjugated to different …

Tripleurospermum limosum (TL) has been used in folk medicine to treat gastritis. Toward the
further development and use of TL, we report the phytochemical profiling, determination of …

A new series of N-thioacylated ciprofloxacin 3a–n were designed and synthesized based on
Willgerodt–Kindler reaction. The results of in vitro urease inhibitory assay indicated that …

Regarding the important role of the urease enzyme as a virulence factor in urease-positive
microorganisms in this study, new series of [1, 2, 4] triazolo [3, 4-b][1, 3, 4] thiadiazole …

Abstract A series of 5-nitrofuran-2-yl-thiadiazole linked to different cyclohexyl-2-
(phenylamino) acetamides were rationally designed and synthesized. All synthetic …

New series of barbiturates linked to aryl hydrazone derivatives 4a-n were designed and
synthesized. Briefly, aniline derivatives in the presence of HBF4 and NaNO2 convert to aryl …

Urease is a metalloenzyme including two Ni2+ ions, found in some plants, bacteria, fungi,
microorganisms, invertebrate animals, and animal tissues. Urease acts as a significant …

Urease is known as a virulence factor of some pathogen in the living organism. In this study,
a novel series of phenylurea conjugated to different alkyl pyridinium were designed …