Serotonin (5-HT) has complex effects on the central nervous system (CNS), neuroendocrine
mechanisms, immunological reactions, intestinal microbiome, and cancer. It has been …

Mast cells are well known to be activated via cross-linking of immunoglobulins bound to
surface receptors. They are also recognized as key initiators and regulators of both innate …

Abstract Background Mast cells (MCs) have been found to play a critical role during
development of inflammatory bowel disease (IBD) that characterized by dysregulation of …

The association between inflammatory processes and intestinal neuronal destruction during
the progression of Chagasic megacolon is well established. However, many other …

Crosstalk between mast cells (MCs) and T lymphocytes (TLs) releases specific signals that
create an environment conducive to tumor development. Conversely, they can protect …

Megacolon is one of the main late complications of Chagas disease, affecting approximately
10% of symptomatic patients. However, studies are needed to understand the mechanisms …

Evidence suggests that natural and adaptive immune responses can trigger neuroendocrine
responses. Here, we discuss changes in the activity of the hypothalamus–pituitary–adrenal …

Background: Several in vitro and in vivo biological activities of serotonin, 5-
hydroxytryptamine (5-HT), as a bioactive molecule, and its transporter (5-HT-Tr) were …

Antecedentes: la enfermedad de Chagas es una zoonosis potencialmente mortal, es
endémica de Sudamérica, donde la mayoría de infectados son asintomáticos y la …

Chagas disease is caused by the parasite, Trypanosoma cruzi that causes chronic cardiac
and digestive dysfunction. Megacolon, an irreversible dilation of the left colon, is the main …