AgRP/NPY and POMC neurons in the arcuate nucleus and their potential role in treatment of obesity
Obesity is a major health crisis affecting over a third of the global population. This
multifactorial disease is regulated via interoceptive neural circuits in the brain, whose …
multifactorial disease is regulated via interoceptive neural circuits in the brain, whose …
The physiological control of eating: signals, neurons, and networks
AG Watts, SE Kanoski, G Sanchez-Watts… - Physiological …, 2022 - journals.physiology.org
During the past 30 yr, investigating the physiology of eating behaviors has generated a truly
vast literature. This is fueled in part by a dramatic increase in obesity and its comorbidities …
vast literature. This is fueled in part by a dramatic increase in obesity and its comorbidities …
LEAP2 changes with body mass and food intake in humans and mice
Acyl-ghrelin administration increases food intake, body weight, and blood glucose. In
contrast, mice lacking ghrelin or ghrelin receptors (GHSRs) exhibit life-threatening …
contrast, mice lacking ghrelin or ghrelin receptors (GHSRs) exhibit life-threatening …
[HTML][HTML] NTS catecholamine neurons mediate hypoglycemic hunger via medial hypothalamic feeding pathways
Glucose is the essential energy source for the brain, whose deficit, triggered by energy
deprivation or therapeutic agents, can be fatal. Increased appetite is the key behavioral …
deprivation or therapeutic agents, can be fatal. Increased appetite is the key behavioral …
Integration of nutrient sensing in fish hypothalamus
JL Soengas - Frontiers in neuroscience, 2021 - frontiersin.org
The knowledge regarding hypothalamic integration of metabolic and endocrine signaling
resulting in regulation of food intake is scarce in fish. Available studies pointed to a network …
resulting in regulation of food intake is scarce in fish. Available studies pointed to a network …
Hypoxia inducible factor as a central regulator of metabolism–implications for the development of obesity
JM Gaspar, LA Velloso - Frontiers in Neuroscience, 2018 - frontiersin.org
The hypothalamus plays a major role in the regulation of food intake and energy
expenditure. In the last decade, it was demonstrated that consumption of high-fat diets …
expenditure. In the last decade, it was demonstrated that consumption of high-fat diets …
Hypothalamic AMPK as a mediator of hormonal regulation of energy balance
As a cellular energy sensor and regulator, adenosine monophosphate (AMP)-activated
protein kinase (AMPK) plays a pivotal role in the regulation of energy homeostasis in both …
protein kinase (AMPK) plays a pivotal role in the regulation of energy homeostasis in both …
AgRP neurons coordinate the mitigation of activity-based anorexia
AK Sutton Hickey, SC Duane, LE Mickelsen… - Molecular …, 2023 - nature.com
Anorexia nervosa (AN) is a debilitating and deadly disease characterized by low body mass
index due to diminished food intake, and oftentimes concurrent hyperactivity. A high …
index due to diminished food intake, and oftentimes concurrent hyperactivity. A high …
ADGRL1 is a glucose receptor involved in mediating energy and glucose homeostasis
KH Chhabra, S Bathina, TS Faniyan, DJ Samuel… - Diabetologia, 2024 - Springer
Aims/hypothesis The brain is a major consumer of glucose as an energy source and
regulates systemic glucose as well as energy balance. Although glucose transporters such …
regulates systemic glucose as well as energy balance. Although glucose transporters such …
Acute inhibition of hunger-sensing AgRP neurons promotes context-specific learning in mice
Objective An environmental context, which reliably predicts food availability, can increase
the appetitive food drive within the same environment context. However, hunger is required …
the appetitive food drive within the same environment context. However, hunger is required …