Novel targets to arrest neurodegeneration in several dementing conditions involving
misfolded protein accumulations may be found in the diverse signaling pathways of the …

Accumulation of dysfunctional and damaged cellular proteins and organelles occurs during
aging, resulting in a disruption of cellular homeostasis and progressive degeneration and …

Regulatory role of Sirtuin 1 (SIRT1), one of the most extensively studied members of its kind
in histone deacetylase family in governing multiple cellular fates, is predominantly linked to …

Neurodegenerative diseases are characterized by the progressive functional loss of
neurons in the brain, causing cognitive impairment and motoneuron disability. Although …

Alzheimer's disease (AD) is one of the fastest growing cognitive decline-related neurological
diseases. To date, effective curative strategies have remained elusive. A growing body of …

Inflammatory bowel disease (IBD) is a chronic inflammatory condition of the gastrointestinal
tract, thought to at least in part reflect an aberrant immune response to gut bacteria. IBD is …

Neurodegenerative disorders are significantly increasing in incidence as the age of the
global population continues to climb with improved life expectancy. At present, more than 30 …

The biological clocks of the circadian timing system coordinate cellular and physiological
processes and synchronizes these with daily cycles, feeding patterns also regulates …

Background: The mammalian circadian clock and its associated clock genes are
increasingly been recognized as critical components for a number of physiological and …

Diabetic mellitus (DM) is a significant public health concern worldwide with an increased
incidence of morbidity and mortality, which is particularly due to the diabetic vascular …