Towards a new combination therapy with vectored immunoprophylaxis for HIV: Modeling “shock and kill” strategy
Q Deng, T Guo, Z Qiu, Y Chen - Mathematical Biosciences, 2023 - Elsevier
Latently infected cells are considered as a major barrier to curing Human Immunodeficiency
Virus (HIV) infection. Reactivation of latently infected cells followed by killing the actively …
Virus (HIV) infection. Reactivation of latently infected cells followed by killing the actively …
Bifurcation analysis and chaos for a double-strains HIV coinfection model with intracellular delays, saturated incidence and Logistic growth
W Chen, L Zhang, N Wang, Z Teng - Mathematics and Computers in …, 2024 - Elsevier
In this paper, a class of virus-to-cell HIV model with intracellular delays, saturated incidence
and Logistic growth is proposed to characterize the interaction between two types HIV …
and Logistic growth is proposed to characterize the interaction between two types HIV …
Modeling the cytotoxicity of Romidepsin reveals the ineffectiveness of this drug in the “shock and kill” strategy
Q Deng, T Guo, Z Qiu, Y Chen - Chaos, Solitons & Fractals, 2023 - Elsevier
The “shock and kill” strategy is being widely explored to purge Human Immunodeficiency
Virus (HIV) latent reservoirs. Romidepsin, a kind of latency-reversing agents (LRAs), has …
Virus (HIV) latent reservoirs. Romidepsin, a kind of latency-reversing agents (LRAs), has …
Theoretical study of diffusive model of HIV-1 infection and its analytical solution
NH Aljahdaly, RA Alharbey, AS Aljohani - Plos one, 2023 - journals.plos.org
T his article studied a mathematical model for the diffusive human immunodeficiency virus-
type 1 (HIV-1) infection combining with stem cell therapy. The HIV-1 infection is a chronic …
type 1 (HIV-1) infection combining with stem cell therapy. The HIV-1 infection is a chronic …
A mathematical model for HIV dynamics with multiple infections: implications for immune escape
Q Deng, T Guo, Z Qiu, Y Chen - Journal of Mathematical Biology, 2024 - Springer
Multiple infections enable the recombination of different strains, which may contribute to viral
diversity. How multiple infections affect the competition dynamics between the two types of …
diversity. How multiple infections affect the competition dynamics between the two types of …
Modeling the Effect of Reactive Oxygen Species and CTL Immune Response on HIV Dynamics
Individuals infected by human immunodeficiency virus (HIV) are under oxidative stress due
to the imbalance between reactive oxygen species (ROS) production and elimination. This …
to the imbalance between reactive oxygen species (ROS) production and elimination. This …
Modeling the effect of activation of CD4 T cells on HIV dynamics.
L Yu, Z Qiu, T Guo - Discrete & Continuous Dynamical …, 2022 - search.ebscohost.com
HIV infects active uninfected CD4++ T cells, and the active CD4++ T cells are transformed
from quiescent state in response to antigenic activation. Activation effect of the CD4++ T …
from quiescent state in response to antigenic activation. Activation effect of the CD4++ T …
Modeling the Cytotoxicity of Latency Reversal Agents Reveals the Ineffectiveness of the'Shock and Kill'Strategy
Q Deng, T Guo, Z Qiu, Y Chen - Available at SSRN 4385123 - papers.ssrn.com
The'shock and kill'strategy is being widely explored to purge Human Immunodeficiency
Virus (HIV) latent reservoirs, but several clinical trials testing this strategy have resulted in …
Virus (HIV) latent reservoirs, but several clinical trials testing this strategy have resulted in …