[HTML][HTML] Phytocannabinoids: origins and biosynthesis

T Gülck, BL Møller - Trends in plant science, 2020 - cell.com
Phytocannabinoids are bioactive natural products found in some flowering plants, liverworts,
and fungi that can be beneficial for the treatment of human ailments such as pain, anxiety …

Recent updates on development of protein-tyrosine phosphatase 1B inhibitors for treatment of diabetes, obesity and related disorders

S Singh, AS Grewal, R Grover, N Sharma, B Chopra… - Bioorganic …, 2022 - Elsevier
The aim of this review was to discuss an overview of type 2 diabetes; biology of PTP1B; role
of PTP1B in metabolic disorders; and recent updates in the development of PTP1B inhibitors …

Current status and contemporary approaches to the discovery of antitumor agents from higher plants

G Agarwal, PJB Carcache, EM Addo… - Biotechnology advances, 2020 - Elsevier
Higher plant constituents have afforded clinically available anticancer drugs. These include
both chemically unmodified small molecules and their synthetic derivatives currently used or …

Emerging strategies for the activity assay and inhibitor screening of alpha-glucosidase

X Zhang, G Li, D Wu, Y Yu, N Hu, H Wang, X Li… - Food & function, 2020 - pubs.rsc.org
The high incidence of diabetes mellitus has caused widespread concern around the world,
and has quickly become one of the most prevalent and costly chronic diseases. Alpha …

Aldose reductase and protein tyrosine phosphatase 1B inhibitors as a promising therapeutic approach for diabetes mellitus

A Kousaxidis, A Petrou, V Lavrentaki… - European Journal of …, 2020 - Elsevier
Diabetes mellitus is a metabolic disease characterized by high blood glucose levels and
usually associated with several chronic pathologies. Aldose reductase and protein tyrosine …

Biosynthesis of bioactive diterpenoids in the medicinal plant Vitex agnus‐castus

AM Heskes, TCM Sundram, BA Boughton… - The Plant …, 2018 - Wiley Online Library
Vitex agnus‐castus L.(Lamiaceae) is a medicinal plant historically used throughout the
Mediterranean region to treat menstrual cycle disorders, and is still used today as a clinically …

Dual high-resolution α-glucosidase and PTP1B inhibition profiling combined with HPLC-PDA-HRMS-SPE-NMR analysis for the identification of potentially antidiabetic …

C Liang, L Kjaerulff, PR Hansen… - Journal of Natural …, 2021 - ACS Publications
Thirteen previously undescribed chromene meroterpenoids, capitachromenic acids A–M (3–
6, 7a, 7b, 8a, 8b, 9a, 9b, 10a, 10b, and 11b), were identified from an ethyl acetate extract of …

Antidiabetic xanthones with α-glucosidase inhibitory activities from an endophytic Penicillium canescens

A Malik, H Ardalani, S Anam, LM McNair… - Fitoterapia, 2020 - Elsevier
Worldwide, 463 million people are affected by diabetes of which the majority is diagnosed
with Type 2 Diabetes (T2D). T2D can ultimately lead to retinopathy, nephropathy, nerve …

[HTML][HTML] Protein tyrosine phosphatase 1B inhibitors from natural sources

BT Zhao, DH Nguyen, DD Le, JS Choi, BS Min… - Archives of pharmacal …, 2018 - Springer
Since PTP1B enzyme was discovered in 1988, it has captured the research community's
attention. This landmark discovery has stimulated numerous research studies on a variety of …

Quadruple high-resolution α-glucosidase/α-amylase/PTP1B/radical scavenging profiling combined with high-performance liquid chromatography–high-resolution …

Y Zhao, KT Kongstad, AK Jäger, J Nielsen… - … of Chromatography A, 2018 - Elsevier
In this paper, quadruple high-resolution α-glucosidase/α-amylase/PTP1B/radical
scavenging profiling combined with HPLC-HRMS-SPE-NMR were used for studying the …