Cancer is a disease caused by the accumulation of genetic and epigenetic changes in two
types of genes: tumor suppressor genes (TSGs) and proto-oncogenes. Extensive research …

Background Biomarkers that can predict the prognosis of colorectal cancer (CRC) patients
and that can stratify high-risk early stage patients from low-risk early stage patients are …

BACKGROUND The development of colorectal cancer (CRC) is a complicated multistep
process that involves an accumulation of mutations in tumor suppressor genes and …

Purpose Gene-specific methylation and expression have shown biological and clinical
importance for breast cancer diagnosis and prognosis. Integrated analysis of gene …

Aims Aberrant DNA methylation is a common molecular feature in human cancer. The aims
of this study were to analyze the methylation status of MLH1, one of the DNA mismatch …

The microsatellite instability (MSI) pathway is found in most cases of hereditary
nonpolyposis colorectal cancer (HNPCC) and in 12% of sporadic colorectal cancer (CRC). It …

Telomeres at the ends of eukaryotic chromosomes play a critical role in tumorgenesis. Using
microfluidic PCR and next-generation bisulfite sequencing technology, we investigated the …

Background and Objectives The aim of the study was to understand the importance of
mismatch repair genes MLH1 and MSH2 in chemotolerance and prognosis of breast …

Results: In our population, the homozygous G/G genotype of the–93G> AMLH1 gene
increased the risk of sporadic CC (OR= 2.07; 95% CI: 1.11–3.83; p< 0.02). For A/G and A/A …

Background A huge array of function is played by the Wnt/β-catenin signaling pathway in
development by balancing gene expression through the modulation of cell-specific DNA …